早期智力干预联合神经节苷脂钠在新生儿缺氧缺血性脑病康复治疗中的作用

摘要

目的：：探讨早期智力干预联合神经节苷脂钠对新生儿缺氧缺血性脑病( HIE)的康复疗效。方法：选择新生儿HIE78例，分为治疗组(神经节苷脂钠+早期智力干预)41例，对照组(单用神经节苷脂钠)37例。于患儿6个月龄时应用Gesell量表评价2组患儿发育商，并进行对比分析。结果：治疗组的大动作能、精细动作能、应物能、言语能、应人能5个能区的发育商评分均高于对照组(P<0.05~P<0.01)。结论：早期智力干预对改善HIE患儿的神经系统发育具有积极作用，能改善脑损伤患儿的感知认知水平。%Objective:To investigate efficacy of combination of early intelligence intervention with monosialotetrahexosylganglioside (GM1) sodium treatment on rehabilitation outcome of neonatal hypoxic-ischemic encephalopathy(HIE). Methods:Seventy-four cases of neonatal HIE were enrolled and randomly assigned into two groups:the treatment group who received both GM1 sodium and early intelligence intervention(41 cases);control group who received GM1 sodium alone(37 cases). The neonates were assessed by the Gesell Development Scale at age of 6 months. Results:The average scores in the treatment group for functions of gross motor, fine motor,language,and social reactions were all higher than that of the control group(P <0. 05 to P <0. 01). Conclusions:Early intelligence intervention led to better neurodevelopmental outcome in neonatal HIE by improving cognitive development and perceptual skills.