基于现代文献分析普通型手足口病证候、证素分布特点及常见证候与症状对应关系

摘要

Objective Through retrospective study of latest 20 years’modern literature related to com-mon hand-foot-mouth disease,the distribution of pattern elements and the relationship between common patterns and corresponding symptoms /signs were analyzed,so as to provide the basis for standardization of TCM pattern differentiation for hand-foot-mouth disease.Methods “hand-foot-mouth disease”OR“hand-foot-mouth”AND “pattern”OR“Chinese medicine”were used as subject words in CNKI,Wan-fang and VIP database to retrieve the relevant literature.Search results were input to establish the stand-ard database by using Epidata 3.0 software,then frequency of symptoms,pattern and pattern elements logistic regression analysis were analyzed by SPSS 17.0.Results The leading symptoms and signs of common hand-foot-mouth disease were rash,fever and anorexia.The common patterns were damp-heat pattern of lung and spleen,pattern of stagnation and steaming of damp-heat and pattern of pathogen inva-ding lung-defense phase.The disease-locations with high frequency were lung,spleen and defense and the disease-natures with high frequency were damp-heat and heat.After Logistic regression analysis,the symptoms/signs of damp-heat pattern of lung and spleen were slobbering and purple venule of index fin-ger,those of pattern of stagnation and steaming of damp-heat were thick tongue coating,high fever and dark,thick venule of index finger,and those of pattern of pathogen invading lung-defense phase were running nose and cough.Conclusion The common patterns types of common hand-foot-mouth disease were damp-heat pattern of lung and spleen,pattern of stagnation and steaming of damp-heat and pattern of pathogen invading lung-defense phase.And the common location elements were lung,spleen and de-fense with the common nature elements of damp-heat and heat.%目的：分析20年手足口病临床研究文献，归纳其证候、证素分布特点及常见证候与症状对应关系，以期为中医药辨证论治手足口病提供参考。方法以主题“手足口病”或者“手足口”和主题“中医”或者“证”作为检索词，从中国期刊全文数据库、维普期刊全文数据库、万方数据资源系统中检索文献，剔除不相关文献，运用 Epidata 3．0软件建立规范数据库，运用 SPSS 17．0软件对症状／体征、证候和证素出现的频次和频率进行统计分析和相关 Logistic 回归分析。结果普通型手足口病症状／体征频次较高的为皮疹、发热和纳差等。证候频次较高的是肺脾湿热证、湿热郁蒸证和邪犯肺卫证。证素方面，频次较高的病位是肺、脾、卫分；病性是湿热、热。Logistic 回归分析，肺脾湿热证最可能的症状依次是口流涎、指纹紫；湿热郁蒸证最可能的症状依次是厚苔、壮热、指纹浓滞；邪犯肺卫证最可能的症状依次是鼻流涕、咳嗽。结论普通型手足口病最常见的证候类型是肺脾湿热证、湿热郁蒸证和邪犯肺卫证；手足口病常见的病位证素为肺、脾、卫分，常见的病性类证素为湿热、热。