静宁颗粒对注意力缺陷多动障碍模型大鼠注意定势转移能力的影响

摘要

Objective To observe the effects of Jingning Granule on attention set shifting (AST) in rats with attention deficit hyperactivity disorder (ADHD).Methods Spontaneously hypertensive rats (SHR) were used as rat model of ADHD.Jingning granule (20.25, 10.125, 5.062 5 g/kg), Methylphenidate HCl Extended-release Tablets (Ritalin 6.75 mg/kg) and pediatric Huanglong granule (0.937 5 g/kg) were used as the intervention respectively and administered continuously for 17 days.The number of errors, burrowing times, and error rate in AST were used as the outcome measures.Results Compared with the normal control group, the number of error, error rate, and burrowing times increased in model group in Simple Discrimination (SD) phase, Compound Discrimination (CD) phase, Intra-Dimensional shift (IDS) phase, Reversal Learning (RL) phase, and Extra-Dimensional shift (EDS) phase;compared with the model group, Jingning granule reduced the frequency of error, error rate, and frequency of burrowing, and improved the attention set shifting defects in ADHD rat model.Conclusion ADHD model rats presented defected attention set shifting, and Jingning granule could effectively improve the attention set transfer ability in ADHD model rats.%目的 观察注意力缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)模型大鼠注意定势转移能力变化及静宁颗粒对其的影响.方法 采用自发性高血压大鼠(spontaneously hypertensive rats,SHR)作为ADHD的模型大鼠,分别给予静宁颗粒(20.25、10.125、5.062 5 g/kg)、盐酸哌甲酯缓释片(利他林6.75 mg/kg)和小儿黄龙颗粒(0.937 5 g/kg),连续给药17 d进行治疗.以大鼠注意定势转移任务(Attentional set-shifting,AST)中错误次数、挖掘次数、错误率等行为学指标,评价药物的药效.结果 与正常对照组比较,模型大鼠在简单辨别(SD)阶段、复杂辨别(CD)阶段、内维度转换(IDS)阶段、逆反学习(RL)阶段、外维度转换(EDS)阶段错误次数、错误率、挖掘次数均增加;与模型组比较,静宁颗粒连续给药17 d后,各剂量可降低模型大鼠错误次数、错误率、挖掘次数,改善ADHD模型大鼠注意定势转移缺陷.结论 ADHD模型大鼠具有注意定势转移缺陷,静宁颗粒可有效改善ADHD模型大鼠的注意定势转移能力.