目的:探讨雄激素受体与蛋白激酶B在三阴性乳腺癌患者中的表达. 方法:收集2011年1月至2014年12月诊断为乳腺癌的患者200例作为本次研究对象,分为观察组(雄激素受体与蛋白激酶B阳性者)100例和对照组(雄激素受体与蛋白激酶B阴性者) 100例. 对比观察组和对照组的肿瘤大小、淋巴结阳性率、组织学分期、辅助化疗率、5年生存率. 结果:观察组与对照组的肿瘤大小、淋巴结阳性率、组织学分期、辅助化疗率、5年生存率比较,差异均有统计学意义( P <0.05). 结论:雄激素受体与蛋白激酶B阳性的三阴性乳腺癌患者肿瘤恶性度高、淋巴结转移率高,预后差,雄激素受体与蛋白激酶B可能与三阴性乳腺癌的发生、发展、浸润和转移有关.%Objective:To investigate the expression of androgen receptor and protein kinase B in three negative breast cancer and analyze their prognostic significance .Methods:200 cases of patients diagnosed with breast cancer from January 2011 to De-cember 2014 in our hospital were randomly divided into the observation group (100 cases), which was positive in androgen recep-tor and protein kinase B and the control group (100 cases), which was negative in androgen receptor and protein kinase B .The tumor size, positive rate of lymph node , histological staging , rate of adjuvant chemotherapy and 5 year survival rate were compared and analyzed between the two groups .Results:There was statistical significance in tumor size , positive rate of lymph node , histo-logical staging, rate of adjuvant chemotherapy and 5 year survival rate between the two groups ( P <0.05).Conclusion: The three negative breast cancer patients with positive androgen receptor and protein kinase B have a high -grade malignancy , higher rate of lymph node metastasis and poor clinical prognosis .Androgen receptor and protein kinase B may be related with occur-rence, development, infiltration and metastasis of three negative breast cancer.
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