非霍奇金淋巴瘤患者化疗前后的C反应蛋白和白蛋白水平变化∗

摘要

Objective:To investigate the changes in the level of C-reactive protein ( CRP) and albumin in non-Hodgkin lymphoma ( NHL) patients with chemotherapy. Methods:72 cases of NHL confirmed by histopathological diagnosis were collected, and the changes in the level of CRP and serum albumin was determined and evaluated before and after chemotherapy. Results:Among the 72 patients, the serum albumin level of 14 patients was less than 35 g/L before chemotherapy, that of 51 patients less than 35 g/L after chemotherapy, with the serum albumin level signifi-cantly lowered and CRP level significantly rose after chemotherapy ( P <0. 05). Patients with hypo-albuminemia developed more severe chemo-therapy-induced reactions. Conclusion:The change in CRP and serum albumin level is a significant indicators to reveal chemotherapy-induced toxicity in non-Hodgkin lymphoma patients.%目的：探讨非霍奇金淋巴瘤( NHL)患者化疗前后C反应蛋白和白蛋白水平的变化。方法：收集72例经组织病理学诊断确诊的NHL患者,在化疗前后分别测定 C 反应蛋白和白蛋白水平的变化并对其进行评价。结果：化疗前14例患者血清白蛋白水平<35 g/L；二周期化疗结束后51例患者血清白蛋白水平<35 g/L,化疗后患者的血清白蛋白水平较化疗前显著降低( P <0.05)；化疗后C反应蛋白的水平较化疗前显著升高( P <0.05)；伴有低白蛋白血症的患者化疗诱导的不良反应更强烈。结论：C反应蛋白和血清白蛋白水平改变,是提示NHL患者化疗毒性有意义的指标。