Effect of Dietary Folic Acid Supplementation on Growth Performance and Hepatic Protein Metabolism in Early-Weaned Intrauterine Growth Retardation Piglets

摘要

cqvip:To investigate the effects of dietary supplementation with folic acid on growth performance,hepatic protein metabolism and serum biochemical indices of early-weaned intrauterine growth retardation(IUGR) piglets,24 male(Duroc×(Landrace×Yorkshire)) weaned(14-d-old) IUGR piglets were randomly divided into 3 treatments with 8 replicates of 1 piglet per replicate.The piglets in each treatment were fed basal diet supplementation with either 0(control),5 and 10 mg kg-1 folic acid.The trial lasted for 21 d.Dietary folic acid supplementation reduced average daily feed intake(ADFI)(P0.05).Serum folic acid concentration increased(P<0.01) with increasing folic acid inclusion,however,serum homocysteine concentration decreased significantly(P<0.01).Enhanced serum urine nitrogen(SUN) and diminished serum total protein(TP) as well as liver TP content were observed in 10 mg kg-1 folic acid group(P<0.05).Furthermore,the relative mRNA expressions of insulin-like growth factor 1(IGF-1) and mammalian target of rapamycin(m-TOR) in liver were respectively tended to reduce(P=0.06) and significantly downregulated(P<0.05) in 10 mg kg-1 group,in compared with 5 mg kg-1 group.However,when compared with control group,folic acid supplementation had no significant effect on the mRNA abundance of IGF-1 and m-TOR.The results indicated that supplementation with 10 mg kg-1 folic acid impaired growth performance and hepatic protein metabolism of early-weaned IUGR piglets while 5 mg kg-1 folic acid enriched diet exerted limited positive effects.