目的：研究艾司西酞普兰联合奥氮平治疗中老年难治性抑郁症临床疗效，判断分析艾司西酞普兰、奥氮平联合治疗效果与影响。方法随机选取2010年1月～2015年12月收治的60例中老年难治性抑郁症患者，分为实验组40例，采用艾司西酞普兰联合奥氮平治疗，对照组20例，采用艾司西酞普兰治疗，对比两组患者临床疗效。结果采用汉密尔顿抑郁量表评定法，实验组患者评分（11.61±2.22）分，评分低于对照组，（14.22±3.51）分，差异具有统计学意义（P＜0.05）。结论艾司西酞普兰联合奥氮平治疗中老年难治性抑郁症在临床表现上具有显著影响效果，它可以在短时间内控制缓解患者焦虑抑郁等情绪，在药效作用上优于单使用艾司西酞普兰药物药效。%Objective To study the escitalopram citalopram in combination with olanzapine treatment the clinical curative effect of senile patients with treatment -resistant depression, judgment analysis of escitalopram citalopram, olanzapine combined treatment effect and influence.Methods Randomly selected from a hospital in January 2010 -December 2015 were 60 cases of senile patients with treatment-resistant depression, divided into experimental group 40 cases, using escitalopram citalopram in combination with olanzapine treatment, the control group, 20 cases with escitalo-pram citalopram treatment, compared two groups of patients with clinical efficacy.Results Using the Hamilton depres-sion rating scale evaluation method, the experimental group patients score (92.61~2.16), score lower than the control group(81.16~4.62), statistically significant difference (P<0.05).Conclusions Escitalopram citalopram in combi-nation with olanzapine treatment of middle-aged and old treatment-resistant depression has significant influence on clinical effect, it can control patients′mood swings, change in a short time, on the therapeutic effects is better than the single use of escitalopram citalopram drug efficacy.
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