乙型肝炎病毒父婴垂直传播的临床研究

摘要

Objective To study the vertical transmission rate of hepatitis B virus from father to infant. Method We enrolled pregnant women who tested negatively to both HBsAg and HBeAg underwent formal examination and delivery. The 100 patients whose spouses were HBV carries were assigned to the study group and the remaining 30 cases whose spouses assayed negatively to HBsAg and HBeAg served as the control group. The serological marker of HBV and HBV-DNA were tested using ELISA and FQ-PCR respectively in the venous blood of the couples and the umbilical blood. Results The positive rate of HBsAg in the umbilical blood of two groups were 0;the positive rates of HBV-DNA in two groups were 27% and 0 respectively. The positive rates did differ significantly between the two groups( P<0. 05 ) . Conclusion Based on the data found in the research,the vertical transmission rate of HBV from father to fetus is very high,but this result need further studies.%目的：观察乙型肝炎病毒（ HBV）父婴垂直传播的几率。方法：选取130例HBsAg和HBeAg均为阴性的孕妇做为研究对象，其中100例其配偶为乙型肝炎病毒携带者的为研究组，其余30例其配偶HBsAg和HBeAg均为阴性的为对照组。用ELISA和FQ-PCR分别检测两组夫妇的静脉血，新生儿脐血的乙肝两对半和HBV-DNA。结果：研究组与对照组新生儿脐血HBsAg阳性率均为0。研究组新生儿脐血HBV-DNA阳性率为27%，对照组新生儿脐血HBV-DNA的阳性率为0，差异有统计学意义（ P<0.05）。结论：就本研究的数据来看，乙型肝炎病毒父婴垂直传播率较高，但本结果有待于进一步研究。