目的：探讨慢性阻塞性肺疾病合并阻塞性睡眠呼吸暂停低通气综合征（亦称重叠综合征，OS）与单纯COPD患者肺功能和睡眠结构的差异。方法：对32例COPD、28例重叠综合征患者分别进行多导睡眠图监测及肺功能测定，并对各组数据作统计学检验。结果：重叠综合征的第一秒用力呼气容积占预计值百分比（ FEV1）、第一秒用力呼气容积占用力肺活量百分比（FEV1/FVC）、最大通气量（MVV）均显著低于COPD组（P<0.01，P<0.05）；同时重叠综合征组的呼吸暂停低通气指数（AHI）、最长呼吸暂停时间（ LAT）和浅睡眠所占百分率（ S1+2）显著高于COPD组，而最低脉氧饱和度（ LSaO2）、平均脉氧饱和度（ MSaO2）、深睡眠所占百分率（ S3+4）显著低于COPD组（ P<0.01，P<0.05）。结论：重叠综合征患者睡眠结构显著改变，夜间缺氧及肺功能受损更严重。%Objective To investigate the characteristics of lung function and changes of sleeping in patients with chronic obstructive pulmonary disease( COPD)and overlap syndrome( OS). Methods Thirty- two patients with COPD and twenty-eight patients with OS were selected for collecting polysomnography( PSG)and lung functions data. The analysis of the data from each group was assessed by t test. Results Forced expiratory volume in one second( FEV1 ),the percentage of FEV1 than forced vital capacit( FEV1/FVC),maximal vol-untary ventilation(MVV)in OS group were significantly lower than that of in COPD group(P<0. 01,P<0. 05). Moreover with in OS group,apnea hypopnea index( AHI),the longest apnea time( LAT),and the percentage of light sleep( S1+2 )were significantly increased, but the lowest oxygen saturation( LSaO2 ),mean oxygen saturation( MSaO2 ),and the percentage of deep sleep( S3+4 )were significantly low-er when compared with COPD groups(P<0. 01,P<0. 05). Conclusion Patients with OS have severe night time hypoxemia concomitant significant changes in sleeping characteristics and obstructive ventilator function.
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