草木犀流浸液片治疗慢性鼻窦炎的疗效观察

摘要

目的：临床观察草木犀流浸液片对慢性鼻窦炎的疗效，探索治疗慢性鼻窦炎疗效好而不良反应少的药物。方法：选取耳鼻咽喉科门诊诊断为慢性鼻窦炎患者120例，随机分成观察组和对照组，每组60例，观察组采用草木犀流浸液片口服，3片/次，3次/d，连续治疗6周；对照组用低剂量克拉霉素250 mg，1次/d，连续治疗6周；观察并记录两组患者治疗前后的视觉模拟分级评分（ VAS）及Lund-Mackey鼻窦CT评分，同时记录患者出现的药物不良反应。结果：观察组治疗前视觉模拟分级评分平均为（7.96±1.85）分，Lund-Mackey鼻窦CT评分平均为（7.16±1.51）分，治疗6周后视觉模拟分级评分平均为（3.28±1.05）分，Lund-Mackey鼻窦CT评分平均为（3.07±1.15）分；对照组治疗前视觉模拟分级评分平均为（8.04±1.79）分，Lund-Mackey鼻窦CT评分平均为（7.08±1.47）分，治疗6周后视觉模拟分级评分平均为（3.41±1.13）分，Lund-Mackey鼻窦CT评分平均为（3.18±1.09）分；观察组和对照组治疗前后组内相比较差异有统计学意义（ P﹤0.05），但两组间相比较，差异无统计学意义（ P﹥0.05）；不良反应方面，观察组患者未见明显不适，而对照组患者有5例出现口腔异味，8例出现轻度失眠，9例出现腹部胀痛和腹泻，观察组明显优于对照组（ P﹤0.05）。结论：草木犀流浸液片治疗慢性鼻窦炎安全有效，无明显不良反应。%Objective Clinical observation on the effect of melilotus extract tablet on chronic sinusitis,explore the drugs in the treat-ment of chronic sinusitis curative effect and less side effect. Method 120 patients with chronic sinusitis outpatient for judgment,were ran-domly divided into observation group and control group,60 cases in each group,the observation group with melilotus extract tablet orally 3 tablets each time,three times a day,continuous treatment for 6 weeks;control group with low dose clarithromycin. In 250 mg,once a day, continuous treatment for 6 weeks;observe and record the two groups before and after treatment in patients with visual analogue score( VAS) and Lund-Mackey sinus CT score,and adverse drug reactions were found. Results The observation group before treatment,visual analogue score averaged(7. 96 ± 1. 85),Lund-Mackey sinus CT score averaged(7. 16 ± 1. 51),6 weeks after the treatment,visual analogue score averaged(3. 28 ± 1. 05),Lund-Mackey sinus CT score averaged(3. 07 ± 1. 15);the control group before treatment. Visual ana-logue score averaged(8. 04 ± 1. 79),Lund-Mackey sinus CT score averaged(7. 08 ± 1. 47),6 weeks after the treatment,visual ana-logue score averaged( 3. 41 ± 1. 13 ),Lund-Mackey sinus CT score averaged( 3. 18 ± 1. 09 );the observation group and the control group before and after treatment in group in comparison,but the difference was significant( P﹤0. 05 )between the two groups were com-pared,the difference was not obvious( P﹥0. 05);adverse reactions,patients in the observation group had no obvious discomfort,while pa-tients in the control group with 5 cases of oral odor,8 cases had mild insomnia,abdominal pain and diarrhea occurred in 9 cases,the obser-vation group was significantly better than the control group(P﹤0. 05). Conclusion Melilotus extract tablet in treatment of chronic sinusitis is safe and effective,no obvious adverse reaction.