硫氧还蛋白相互作用蛋白与2型糖尿病及胰岛素抵抗的相关性

摘要

目的 探讨硫氧还蛋白相互作用蛋白(TXNIP)与2型糖尿病(T2DM)及胰岛素抵抗的关系.方法 采用ELISA法检测T2DM组(A组,54例)及正常对照组(B组,30例)患者血清TXNIP水平,同时检测糖化血红蛋白(HbAlc)、空腹血糖(FPG)、胰岛素(FINS)及血脂.结果 A组血清TXNIP水平显著高于B组(P＜0.05).TXNIP与FPG、HbAlc、胰岛素抵抗指数(HOMA-IR)呈显著正相关(P＜0.01); HbAlc和HOMA-IR是TXNIP的独立影响因素.结论 TXNIP可能参与了T2DM及胰岛素抵抗的病理生理过程.%Objective To explore the correlation of thioredoxin-interacting protein (TXNIP) with type 2 diabetes mellitus(T2DM) and insulin resistance. Methods Serum TXNIP was measured by ELISA in 54 T2DM patients (group A) and 30 healthy controls (group B). Glycosylated hemoglobin Alc(HbAlc), fasting plasma glucose (FPG), insulin (Fins) and blood lipid were measured as well. Results Serum level of TXNIP was higher in group A than that in group B(P<0. 05), which was positively correlated to FPG, HbAlc and homeostasis model assessment for insulin resistance (HOMA-IR)(P<0. 01). HbAlc and HOMA-IR were the independent factors for determining serum TXNIP concentration. Conclusion TXNIP may participate in the process of developing T2DM and insulin resistance.