前列腺素E1治疗亚急性乙型重型肝炎的临床疗效

摘要

目的 观察前列腺素E1(PGEl)对亚急性乙型重型肝炎治疗的临床疗效.方法 63例亚急性乙型重型肝炎患者随机均分为治疗组(33例)和对照组(30例).两组采用甘草酸二铵(甘利欣)、促肝细胞生长素、门冬氨酸钾镁、多种维生素、人血白蛋白、血浆等常规治疗;治疗组加用PGE1注射液10 μg,每日1次.疗程均为4周.检测治疗前和疗程结束后的血直接胆红素、总胆红素、丙氨酸氨基转移酶/谷氨酸氨基转移酶.结果 两组治疗后肝功能均有明显改善;治疗组血清总胆红素明显低于对照组[(64.3±25.4)μmol/L vs.(82.4±35.2)μmol/L](P＜0.05).治疗组有效率明显高于对照组(81.8％vs.70.0％)(P＜0.05).结论 加用PGE1能明显改善亚急性乙型重型肝炎的治疗效果.%Objective To observe the clinical efficacy of prostaglandin EKPGE1) in treating severe subacute hepatitis B(SSHB). Methods A total of 63 patients with SSHB were equally randomized into two groups. The patients in group BOO cases) were conventionally treated with diammonium glycyrrhzinate, hepatocyte growth promoting factor, potassium magnesium aspartate, vitamins,albumin and plasm. The patients in group A(33 cases) were given additional PGE1 10 fig, which was diluted in 5% glucose 250 ml and infused once a day for 4 weeks as a therapeutic cycle. Serum total bilirubin,direct bilirubin,alanine aminotransferase( ALT) and aspartate aminotransferase (AST) were measured before and at the end of treatment and clinical outcomes were compared. Results The liver function was significantly improved after treatment in both groups. Serum total bilirubin was lower in group A than that in group B[(64. 3+25. 4) μmol/L vs. (82. 4±35. 2) μmol/L](P<0. 05). The effectiveness rate was higher in group A than that in group B(81. 8% vs. 70. 0%)(P<0. 05). Conclusion Additional use of PGE1 may effectively improve therapeutic efficacy in the patients with SSHB.