精神分裂症患者攻击行为与5-HTTLPR多态性的关联研究

摘要

Objective To explore the association of the polymorphisms of serotonin transporter gene-linked polymorphic region (5-HTTLPR) with aggression behavior in schizophrenia. Methods 195 patients who met the diagnostic criteria for schizophrenia on DSM-IV were recruited and divided into aggressive and non-aggressive groups according to their scores of the Modified Overt Aggression Scale (MOAS). 99 patients who had a total weighted MOAS score of≥ 4 were as aggressive subjects, and the other 96 patients who had a score of zero were as non-aggressive controls. 5-HTTLPR polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results The distribution of genotypes or alleles of the 5-HTTLPR polymorphisms did not differ significantly between the two groups (P >0.05), neither after stratification by male and female in both groups (P>0.05). Conclusions 5-HTTLPR polymorphisms are not associated with aggression behavior in schizophrenia.%目的 探讨精神分裂症患者的攻击行为与5-HTTLPR多态性的相关性.方法 采用<修订版外显攻击行为量表>(MOAS)对符合美国<精神障碍统计与诊断手册第4版>(DSM-Ⅳ)的精神分裂症患者进行评定,99例MOAS加权总分≥4分者为有攻击行为组(攻击组),96例MOAS加权总分0分者为无攻击行为组(非攻击组).应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术检测受试者的5-HTTLPR多态性.结果 攻击组的基因型分别为SS 38例、SL 44例、LL17例,等位基因频率分布分别为S 120例、L 78例;非攻击组间的基因型分别为SS40例、SL 39例、LL 17例,等位基因频率分布分别为S 119例、L73例,两组比较差异无显著性(P＞0.05).按性别分层后分析,两组间的基因型和基因频率分布差异亦无显著性(P＞0.05).结论 未见5-HTTLPR多态性与精神分裂症患者的攻击行为存在关联.