脑室内注射万古霉素并腰大池引流对颅内耐甲氧西林金黄色葡萄球菌感染的治疗分析

摘要

目的 观察应用万古霉素脑室内注射并腰大池引流对术后颅内耐甲氧西林金黄色葡萄球菌感染的治疗效果.方法 对12例术后颅内耐甲氧西林金黄色葡萄球菌感染患者采用脑室内注射万古霉素并持续腰大池外引流,在治疗前后监测患者体温、血白细胞、颅内压、脑脊液常规、生化指标及细菌培养.结果 治疗前各指标显著异常,治疗2～3d后逐渐恢复,5～7d基本正常,治疗前后对比各指标差异明显P＜0.05或P＜0.01,无并发症发生.结论 脑室内注射万古霉素并持续腰大池外引流治疗颅内耐甲氧西林金黄色葡萄球菌感染疗效显著,操作简便,是临床治疗颅内耐甲氧西林金黄色葡萄球菌感染的可行方法.%Objective To observe the effect of intracerebroventricular injection of vancomycin combined with continuous drainage in the terminal cistern of spinal canal on intracranial infection caused by methicillin-resistant staphylococcus aureus.Methods 12 patients with intracranial infection caused by methicillin-resistant staphylococcus aureus were treated with intracerebroventricular injection of vancomycin combined with continuous drainage in the terminal cistern of spinal canal.And observe the body temperature,blood leucocyte,intracranial pressure,and cerebrospinal fluid.Results All the indexes were abnormal before intracerebroventricular injection,gradually improved after 2 or 3 days,and became normal after 4 to 7 day.There were significant differences in all the indexes before and after the treatment( P＜0.05 or P＜0.01 ).Conclusion Intracerebroventricular injection of vancomycin combined with continuous drainage in the terminal cistern of spinal canal on intracranial infection caused by methicillin-resistant staphylococcus aureus is effective,practicable,and safe.