思连康联合常规抗菌治疗对细菌性肠炎患儿炎性因子表达的影响

摘要

Objective To study the effect of Siliankang combined with routine antibiotic therapy on the expression of inflammatory factors in children with bacterial enteritis.Methods 120 children with bacterial enteritis treated at our hospital from July,2014 to July,2015 were selected as study objects and were randomly divided into a control group and an observation group,60 cases for each group.The control group were treated with routine antibiotic therapy;in addition,the observation group were treated with Siliankang.The curative effects and the changes of the levels of inflammatory factors before and after treatment in these two groups were observed.Results The total effective rate of the observation group (96.67％) was significantly higher than that of the control group (85.00％) (P ＜ 0.05).After the treatment,TNF-α,IL-1βand IL-8 in the observation group [(1.13±0.21) pg/ml,(8.01 ± 1.21) pg/ml,(7.22± 1.27) pg/ml] were significantly lower than those before treatment and those in the control group (P ＜ 0.05).Conclusions Siliankang combined with routine antibiotic therapy in the treatment of pediatric bacterial enteritis can significantly reduce the levels of TNF-α,IL-1β,IL-8,and other inflammatory cytokines and improve gastrointestinal function.The curative effect is remarkable.%目的 研究思连康联合常规抗菌治疗对细菌性肠炎患儿炎性因子表达的影响.方法 选择2014年7月至2015年7月来本院就诊的120例细菌性肠炎患儿作为研究对象,随机分为两组,每组60例.对照组给予常规抗菌药物治疗,观察组在此基础上联合思连康治疗,观察两组治疗效果和治疗前后炎症因子水平变化情况.结果 观察组治疗后总有效率为96.67％,显著高于对照组的85.00％,差异具有统计学意义(P＜0.05).观察组治疗后TNF-α、IL-1β及IL-8分别为(1.13±0.21)pg/ml、(8.01±1.21)pg/ml及(7.22±1.27) pg/ml,显著低于治疗前和对照组治疗后,差异具有统计学意义(P＜0.05).结论 思连康联合常规抗菌药物治疗小儿细菌性肠炎可显著降低TNF-α、IL-1β及IL-8等炎性细胞因子水平,改善胃肠功能,疗效显著.