雷替曲塞化疗联合放疗对局部晚期直肠癌患者治疗效果和毒副作用及预后的影响

摘要

Objective To investigate the effects ofraltitrexed chemotherapy combined with radiotherapy on the therapeutic effect,side effect,and prognosis of patients with locally advanced rectal cancer.Methods 80 patients with locally advanced rectal cancer treated at our hospital from May,2014 to May,2016 were selected and were divided into a raltitrexed chemotherapy combined with radiotherapy group (raltitrexed group,n=40) and a 5-fluorouracil chemotherapy combined with radiotherapy group (5-fluorouracil group,n=40) according to treatment methods.The clinical curative effects and incidences of adverse reactions of the two groups were statistically analyzed.Results The total remission rate was significantly higher in the raltitrexed group than in the 5-fluorouracil group [60.0％ (24/40) vs.27.5％ (11/40)] (P ＜ 0.05).The incidences of grade Ⅰ-Ⅱ nausea and vomiting and transaminase increase were significantly lower in the raltitrexed group than in the 5-fluorouracil group (both P ＜ 0.05).Conclusions Raltitrexed chemotherapy combined with radiotherapy can more effectively improve the treatment effect,reduce the side effects more,and improve the prognosis of patients with locally advanced rectal cancer more than 5-fluorouracil,so it is worth being generalized.%目的 探讨雷替曲塞化疗联合放疗对局部晚期直肠癌患者治疗效果、毒副作用及预后的影响.方法 选取本院2014年5月至2016年5月收治的局部晚期直肠癌患者80例,依据治疗方法将这些患者分为雷替曲塞化疗联合放疗组(雷替曲塞组,n=40)和5-氟尿嘧啶化疗联合放疗组(5-氟尿嘧啶组,n=40),对两组临床疗效、毒副反应发生情况进行统计分析.结果 雷替曲塞组总缓解率[60.0％(24/40)]显著高于5-氟尿嘧啶组[27.5％(11/40)](P＜0.05),I～Ⅱ级恶心呕吐、转氨酶升高发生率均显著低于5-氟尿嘧啶组(P＜0.05).结论 雷替曲塞较5-氟尿嘧啶化疗联合放疗更能有效提升局部晚期直肠癌患者的治疗效果,减轻毒副作用,从而有效改善患者预后,值得推广.