Tooth development involves a series of interactions between the oral epithelium and cranial neural crest-derived mesenchymal cells. These interactions progressively transform the tooth primordia into complex mineralized structures. Cell-cell interactions play complementary roles in allowing plasticity during tooth morphogenesis and stabilization at later stages of epithelial histogenesis. This article reviews the role of cell-cell interactions mediated by adherens junctions formed by cadherins and communicative gap junctions formed by connexins in regulating tooth development.%口腔上皮和源于颅神经嵴的间叶细胞间相互作用,牙原基发育形成为复杂的钙化组织.细胞间复杂有序地相互作用导致牙形态发生并保持稳定.本文就牙发育过程中参与细胞间相互作用的黏附连接与钙黏着蛋白、钙黏着蛋白与牙发育,缝隙连接与缝隙连接蛋白、缝隙连接蛋白与牙发育等研究进展作一综述.
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