Objective To explore the similarities and differences of the expression of interleukin (IL) -17 and 23 between the group of peri-implantitis and peri-implantar healthy patients. To determine the effect and mutual relations of IL-17 and 23 in the development and progression of peri-implantitis. Methods Implant cases were divided into health-implant group and peri-implantitis group, the health of natural teeth of the opposite side with the same name as the control group. The peri-implant sulcular fluid were collected to determine the concentration of IL-17 and IL-23 by using enzyme-linked immunosorbent assay method. Results In the peri-implant sulcular fluid of the peri-implantitis, the concentration of IL-17 and 23 was significantly higher than that in the implant group (P<0.01), health-implant group was slightly higher than that in the control group (P<0.05). The volume of implant and natural periodontal gingival crevicular fluid, and IL-17 and 23 had a positive correlation with periodontal status. There was a significant positive correlation between the concentration of IL-17 and IL-23 in the peri-implantitis group. Conclusion The concentration of IL-17 and IL-23 were positively correlated with the incidence of peri-implantitis. IL-17 and IL-23 can form IL-23-IL-17 immune response pathway in the incidence of peri-implantitis.%目的 探讨白细胞介素(IL)-17和23在正常种植体和种植体周围炎中表达的异同,两者在种植体周围炎发生发展过程中的作用和相互关系.方法 根据种植体周情况将其分为健康种植体组和炎症种植体组,以对侧同名健康天然牙为对照组.采集龈沟液并测量其体积,运用夹心酶联免疫吸附试验测定IL-17和23的质量浓度.结果 在种植体周围炎患者龈沟液中,IL-17和23的质量浓度明显高于健康种植体组(P<0.01),健康种植体组略高于对照组(P<0.05).种植体周和天然牙周龈沟液的体积以及IL-17和23与牙周状况呈正相关关系,种植体周围龈沟液中IL-17与23呈线性正相关.结论 IL-17和23的质量浓度与种植体周围炎的发生相关,种植体周IL-17与23间的质量浓度呈正相关,即IL-17和23可能在种植体周围炎症反应过程中形成了IL-23-IL-17免疫应答途径.
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