睾丸孤核受体4（TR4）促进巨噬细胞向前列腺癌浸润

摘要

Objective:To investigate the role of testicular orphan receptor 4 (TR4) in the recruitment of human macrophage THP-1 cells in prostate cancer. Methods:Transwell system was used in the study of cellular migration to measure the THP-1 recruitment ability of prostate cancer (PCa) cells with varying levels of TR4;human PCa tissue was collected to study the relation of TR4 levels and CD36 levels by IHC staining. Results:Over-expression of TR4 increased THP-1 migration in PCa cells, knocking-down TR4 could decrease the THP-1 migration in PCa cells;IHC staining demonstrated that TR4 levels positively correlate with CD36 levels. Conclusion:TR4 may promote THP-1 cells inifltration in prostate cancer.%目的：研究前列腺癌TR4水平对巨噬细胞浸润的影响。方法：用transwell体系进行巨噬细胞THP-1迁移实验，在人体组织中研究睾丸孤核受体4(Testicular orphan receptor 4，TR4)水平和巨噬细胞标志物CD36的关系。结果：过表达TR4促进了巨噬细胞向前列腺的迁移；敲低TR4抑制了巨噬细胞向前列腺癌的迁移；人体前列腺癌组织标本中TR4较高的患者，CD36表达较高。结论：前列腺癌的TR4可能促进了巨噬细胞浸润。