2型糖尿病与阻塞性睡眠呼吸暂停低通气综合征

摘要

2型糖尿病(type 2 diabetes mellius,T2DM)患者中存在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的高患病率,OSAHS患者又常合并T2DM,二者同时存在,互为加重因素,使心脑血管意外的发生几率大大增加.近期研究指出OSAHS与T2DM存在独立相关性,多种机制可用于解释其相互作用的发生,血浆尾加压素II (urotensin II,UII)、瘦素、Ghrelin、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)等在T2DM与OSAHS相关性中起作用.对于T2DM合并OSAHS患者的有效治疗方案存在一定争议,本文就从流行病学、T2DM与OSAHS相互作用的可能机制,目前较多研究的相关性因子,以及对T2DM合并OSAHS的治疗方案选择方面做一综述.%There is a high morbidity rate of OSAHS in the T2DM patients.The two diseases often occur in the same time and even exacerbateeach other,which leads to a high risk of cardiovascular events.In resent research,there is a point that OSAHS is independently associated with T2DM and much mechanism can account for it.UII,Leptin,Ghrelin,TNF-α and other factors may play a role in the development of OSAHS associated with type 2 diabetes.There are also some arguments about the effective treatments on patients with OSAHS and T2DM.This review aimed to give a summary on the epidemiology,the possible mechanism,the impact factors and treatments about the Patients with OSAHS and T2DM.