系统性红斑狼疮患者血清诱骗受体3和细胞因子间关系的探讨

摘要

Objective To investigate the level of decoy receptor 3(DcR3) and the characteristics of IFN-Y/lL-4 pattern in patients with systemic lupus erythematosus (SLE) .Methods 36 patients with SLE and 32 healthy volunteers as controls were included in the study .Serum levels of DcR3,IL-4 and IFN-Y were determined by donble-antibody-sandwich enzyme linked immnnosorbent assay(ELISA) .Results Compared with the healthy volunteers,significantly higher serum DrR3,IFN-Y and IL-4 concentrations were detected in SLE patients (P<0 .01) .DcR3 correlated positively with IL-4(r=0 .340,P<0 .05)and negatively with IFN-y/lL-4 ratio ( r= - 0.332,P<0 .05),while no correlation was observed between DcR3 and IFN-r(r= - 0 .105, P>0 .05) .Conclusion DcR3 might be involved in the development of SLE .Thl/Th2 cytokines pattern might be complex in SLE and different in individual SLE patients .DcR3 might promote T helper cells transforming into Th2 cells to some extent in SLE patients .%目的 探讨诱骗受体3(DcR3)与γ-干扰素/白细胞介素-4(IFN-γ/IL-4)分泌模式在系统性红斑狼疮(SLE)患者免疫紊乱过程中发生的变化及两者的关系.方法 采用ELISA双抗体夹心法检测36例SLE患者和32例健康者血清中DcR3、IL-4 和IFN-γ的水平.结果 SLE患者血清DcR3、IFN-γ和IL-4 水平显著升高(P＜0.01);DcR3 与IL-4 呈正相关(r=0.340,P＜0.05),与IFN-γ 无明显相关关系(r=-0.105,P＞0.05),与IFN-γ/IL-4 呈负相关(r＝-0.332,P＜0.05).结论 SLE 患者血清DcR3 水平显著升高,可能参与SLE 的发生发展过程;SLE 患者Th1/Th2 细胞因子分泌模式复杂,不同患者可能分别表现为Th1细胞或Th2细胞优势;SLE 中DcR3 具有一定的促Th2 偏移作用.