太原地区HPV感染基因型分布与不同年龄段的相关性研究

摘要

目的 分析太原地区不同年龄段妇女人乳头瘤病毒(HPV)感染状况及基因型分布特点.方法 利用导流杂交基因芯片技术,对901例妇女阴道分泌物进行HPV分型检测,并对检测结果进行相关性分析.结果 901例标本中HPV阳性检出率为41.73%,其中单一感染、2型感染、多型感染的感染率分别为67.55%、21.28%、11.17%.HPV感染者中检出率较高的亚型为16型(10.54%)、6型(6.33%)、11型(5.44%)、52型(5.22%)和58型(4.33%);16～24岁、25～34岁、35～44岁、45～54岁、≥55岁各年龄段人群中HPV感染率分别57.43% 、42.60% 、35.45% 、31.25% 、51.56%,差异有统计学意义(χ2=31.94,P<0.05).结论 太原地区HPV感染以单一感染为主,与年龄分布具有相关性.%Objective To investigate the relationship between sub-type HPV infection and different age groups in Taiyuan region . Methods The status of HPV infection in 901 patients were examined by flow through hybridization and genechip technique, The various sub-types of HPV were analyzed with statistical . Results HPV infection rate of the 901 patients was 41 .73% .Among them,67 .55/o were infected by single HPV genotype,21 .28/o were infected by two genotypes and 11.17/o were infected by three genotypes .In the; positive; rates of HPV,The percentages of 16,6,11,52,58,were 10 .54%,6 .33%,5 .44%,5 .22%,4 .33% respectively ;For different age groups (16 - 24,25 -34,35 - 44,45 -54>55 ),The age-specific prevalence of HPV was 57.43%, 42.60%,35.45%,31.25%,51.56% respectively .Statistics difference was noted between these cases (x2=31 .94,P<0 .05) .Conclusion HPV infection situation was comparatively severe and mostly were single infection in the Taiyuan area,age certainly had something to do with HPV infection.