网织血小板在慢性肝病合并血小板减少症中的意义

摘要

Objective To investigate the reticulocytes platelet changes and significance in chronic liver disease combined thrombocytopenia.Methods The IPF％ and IPF absolute value of 117 patients with chronic liver disease,47 patients with ITP and 89 cases of normal control were measured by the XE-5000 automated hematology analyzer.The chronic liver disease group was divided into chronic liver disease associated with normal platelets group and chronic liver disease associated with thrombocytopenia group.Results The IPF％ median of chronic liver disease associated with thrombocytopenia group was higher than that of the normal control group (P＜0.01) and the chronic liver disease associated with the platelet normal group (P＜0.01),and was lower than that of the ITP group (P＜0.01).The IPF％ median of ITP group and chronic liver disease associated with normal platelet group were higher than that of the control group (P＜0.01).The IPF absolute value median of chronic liver disease associated with thrombocytopenia group and the ITP group were lower than that of the control group (P＜0.01).There was no significant difference of IPF absolute value between the chronic liver disease group and the normal control group (P＞0.05).Conclusion The reticulated platelets can reflect bone marrow megakaryocytes to produce platelets in chronic liver disease associated with thrombocytopenia,and it is helpful for diagnosing the causes of thrombocytopenia in chronic liver disease.%目的 探讨网织血小板在慢性肝病性伴血小板减少症中的变化及意义.方法 采用XE-5000全自动血液分析仪分别测定117例慢性肝病患者、47例ITP患者和89例健康人群外周血IPF％和IPF绝对值,并将慢性肝病组分为慢性肝病伴血小板正常组、慢性肝病伴血小板减少组.结果 慢性肝病伴血小板减少组IPF％中位数高于健康对照组(P＜0.01),高于慢性肝病伴血小板正常组(P＜0.01),低于ITP组(P＜0.01),ITP组和慢性肝病伴血小板正常组IPF％中位数高于健康对照组(P＜0.01).慢性肝病伴血小板减少组和ITP组IPF绝对值低于健康对照组(P＜0.01),慢性肝病伴血小板正常组IPF绝对值与健康对照组间差异无统计学意义(P＞0.05).结论 网织血小板可反映慢性肝病伴血小板减少者骨髓巨核系统生成血小板情况,有利于慢性肝病患者血小板减少病因的诊断.