胃泌素释放肽前体、组织多肽特异性抗原和神经元特异性烯醇化酶联合检测在临床小细胞肺癌患者治疗监测中的应用

摘要

目的 探讨胃泌素释放肽前体(ProGRP)、组织多肽特异性抗原(TPS)及神经元特异性烯醇化酶(NSE)检测在小细胞肺癌(SCLC)患者治疗监测中的应用.方法 选择该院收治的SCLC患者58例作为SCLC组,同时选取健康者50例作为对照组,进行测定ProGRP、TPS及NSE的测定并分析.结果 各组ProGRP、TPS、NSE浓度差异均有统计学意义(ProGRP:x2=49.86,P=0.00；TPS:x2=35.17,P=0.00;x2=77.64,P=0.00)；ProGRP、TPS、NSE单独检测用于诊断的敏感度分别为78.3％、60.4％、72.2％,特异度分别为95.1％、79.2％、92.5％；3项指标进行联合检测时,ProGRP+ TPS、ProGRP+ NSE、TPS+NSE和ProGRP+ TPS+ NSE组合的敏感度分别为88.6％、92.7％、85.4％、92.7％；特异度分别为77.1％、90.1％、71.3％、77.1％.ProGRP、TPS和NSE的浓度在不同治疗阶段的差异均有统计学意义(ProGRP:x2=46.21,P=0.00;TPS:x2=11.15,P=0.00；NSE:x2=42.83,P=0.00).3组指标的浓度对不同预后的差异均有统计学意义(ProGRP:x2=51.24,P=0.00;TPS:x2 =27.16,P=0.00;NSE:x2 =38.85,P=0.00).结论 ProGRP、TPS和NSE在SCLC患者血清中均高表达,合理的联合检测有助于对SCLC患者进行准确诊断、疗效检测和预后评价.%Objective To explore the application of the detection of ProGRP,TPS,and NSE in the patients with small cell lung cancer(SCLC). Methods 58 patients with SCLC in the hospital were recruited as SCLC group. Meanwhile, 50 health people were recruited as the control group. ProGRP,TPS and NSE of all subjects were measured and analyzed. Results The difference of the concentration of ProGRP,TPS and NSE in each group were statistically significant (ProGRP: X2 =49. 86,P = 0. 00;TPS:X2= 35. 17,P = 0. 00;X2 = 77. 64,P = 0. 00). The sensitivity of ProGRP,TPS and NSE were 78. 3%,60. 4% and 72. 2% respectively. The specificity was 95. 1% ,79. 2% and 92. 5%,respectively. When the three indicators were combined detected, the sensitivity of ProGRP±TPS,ProGRP±NSE,TPS±NSE and ProGRP ± TPS ± NSE were 88. 6%,92. 7%,85. 4% and 92. 7% , respectively, while the specificity was 77. 1% ,90. 1% ,71. 3% and 77. 1%. The differences of the concentrations of ProGRP, TPS and NSE in different treatment stages were statistically significant(ProGRP:X2 =46. 21 ,P = 0. 00;TPS:X2 = 11. 15,P = 0. 00;NSE:X2 =42. 83, P = 0. 00). The differences of the concentrations of the three indicators in different outcomes were statistically significant (ProGRP: X2=51. 24,P = 0. 00;TPS:X2=27. 16,P = 0.00;NSE:X2 =38. 85,P = 0. 00). Conclusion High expression was found in ProGRP, TPS and NSE of SCLC patients. A reasonable combined detection is helpful for accurate diagnosis of SCLC,efficacy detection and outcome evaluation.