未成熟网织红细胞分数对评估38例恶性肿瘤患者放疗后造血功能恢复情况的分析

摘要

Objective To investigate the clinical value of immature reticulocyte fraction(IRF) in evaluating the recovery of blood-producing function after radiotherapy.Methods Count number of absoluteneutrophilic granulocyte count(ANC) , percentage of reticulocyte(RKT%) and IRF in 38 patients with malignant tumor before and after radiotherapy was detected by Sysmex XE-2100 automated hematology analyzer and the results were compared.Results After radiotherapy, IRF, ANC and RET% were significantly decreased(P<0.05).IRF, ANC and RET% began to increase with duration of recovery.On the 20th day, there were no significant changes in the level of IRF between post-radiotherapy and pre-radiotherapy(P>0.05).While ANC and RET% were still significantly lower than those of pre-radiotherapy(P<0.05).Conclusion IRF could be an early indicator of haematopoietic function recovery after radiotherapy, and it could be applied to monitor hemopoietic recovery after radiotherapy, observe pathoge-netic condition and guide the treatment.%目的 探讨采用未成熟网织红细胞分数(IRF)监测恶性肿瘤患者放疗后造血功能恢复的临床价值.方法 采用Sysmex XE-2100全自动血细胞分析仪检测38例恶性肿瘤患者的中性粒细胞绝对计数(ANC)、网织红细胞百分比(RET%)及IRF,并对结果进行对比分析.结果 38例恶性肿瘤患者放疗后ANC、RET%及IRF与放疗前相比均明显降低(P<0.05).随着恢复时间的延长,各指标均开始回升,第20天时IRF与化疗前相比差异无统计学意义(P>0.05),而ANC及RET%仍显著低于放疗前水平(P<0.05).结论 IRF是恶性肿瘤患者放疗后造血功能恢复较敏感的指标,可用于造血功能恢复的监测、病情观察及指导临床治疗.