目的：探讨染色体变异、畸变与男性生殖激素水平和精子生成的关系。方法对147例男性不育和复发性流产患者进行染色体核型、生殖激素和精液分析，并对其结果进行对比分析。结果染色体畸变组血清 FSH、LH 水平和无精子症发生率分别高于染色体变异组和正常组（P ＜0.05，P ＜0.01），血清 T 水平显著低于染色体变异组和正常组（P ＜0.05）。Y 染色体变异组血清 FSH 水平和少精子症发生率显著高于常染色体变异组（P ＜0.05），两组无精子症发生率差异无统计学意义（P ＞0.05）。性染色体畸变组血清 FSH、LH 水平和无精子症发生率显著高于常染色体畸变组（P ＜0.05），血清 T 水平显著低于常染色体畸变组（P ＜0.05）。结论染色体变异、畸变与生殖激素紊乱和生精功能障碍密切相关，性染色体变异和畸变导致男性血清 FSH、LH水平显著升高、T 水平显著降低可能是导致少精子症和无精子症的发病机制之一。%Objective To investigate the association between chromosome variations,abnormalities and male reproductive hor-mones level with spermatogenesis.Methods The chromosome karyotype,serum reproductive hormone including FSH,LH,T,PRL and E2,and semen were detected in 147 patients with male infertility or recurrent sponotaneous abortion.The results were per-formed the comparative analysis.Results Serum FSH,LH level and the incidence rate of azoospermia in the chromosome abnormal-ity group were significantly higher than those in the chromosome variation group and the normal group(P <0.05,P <0.01),serum T level was significantly lower than that in the chromosome variation group and the normal group(P <0.05).Serum FSH and the incidence rate of oligospermia in the Y chromosome variation group were significantly higher than those in the autosomal variation group(P <0.05).The incidence rate of azoospermia had no statistically significant difference between the Y chromosome variation and the autosomal variation group(P >0.05).Serum FSH,LH level and the incidence rate of azoospermia in the sex chromosome abnormality group were obviously higher than those in the autosomal abnormality group(P <0.05),the serum T level was signifi-cantly lower than that in the autosomal abnormality group(P <0.05).Conclusion The chromosome variation and abnormality are closely related with the reproductive hormones disorder and spermatogenetic function disorder.The obvious increase of serum FSH, LH level and obvious decrease of T level caused by sex chromosome variation and abnormality is one of the pathogenesis of oligo-spermia and azoospermia.
展开▼
