C反应蛋白、淀粉酶及脂肪酶联合检测在急性胰腺炎早期诊断中的作用

摘要

目的：探讨针对急性胰腺炎患者开展 C 反应蛋白、淀粉酶与脂肪酶联合检测的早期诊断价值，以及对病变程度的评估效果。方法选取该院2012年3月至2014年3月收治的急性胰腺炎患者71例，其中轻型胰腺炎患者60例，重型胰腺炎患者11例，同时以30例非急性胰腺炎急腹症患者作为对照 A 组，并选取同期于本院体检合格的健康成年人50例作为对照 B 组。分别开展 C 反应蛋白、淀粉酶以及脂肪酶的临床检测，并将获取结果进行比较与分析。结果急性胰腺炎患者血清淀粉酶水平为（759．42±721．63）U／L，血清脂肪酶水平为（1624．34±1598．25）U／L，均高于对照 A 组与对照 B 组，差异有统计学意义（P ＜0．05）。但患者的 C 反应蛋白水平为（44．61±34．21）mg／L，与对照 B 组比较差异无统计学意义（P ＞0．05）。三种指标联合检测用于早期急性胰腺炎诊断的灵敏度为95．9％，特异度为100．0％，准 确 度为96．9％，均高于其他检测方式，差 异有统计学意义（P ＜0．05）。结论针对急性胰腺炎患者开展 C 反应蛋白、淀粉酶与脂肪酶联合检测，不但具有明确的早期诊断效果，而且对疾病程度的判断具有参考价值。%Objective To evaluate the diagnostic value of combined test of C-reactive protein,amylase and lipase for acute pan-creatitis patients in early stage,and its practicability in assessment of disease severity.Methods 71 cases of acute pancreatitis pa-tients in the hospital from March 2012 to March 2014 were enrolled in the study,including 60 cases of mild pancreatitis patients,11 cases of severe pancreatitis patients.Meanwhile,30 cases of non-acute pancreatitis patients were enrolled as Control Group A,and 50 cases of adults who underwent conventional examination and proved to be healthy were enrolled as Control Group B.Detection of C-reactive protein,amylase and lipase of these samples were performed and the results were recorded,compared and analyzed.Re-sults The serum amylase level of acute pancreatitis patients was (759.42±721.63)U/L,and serum lipase level were (1 624.34± 1 598.25)U/L,which were significantly higher than people in Control Group A and Control Group B,with statistical significance (P <0.05).However,C-reactive protein level of acute pancreatitis patients were (44.61±34.21)mg/L,which were not statistical-ly different compared with Control Group B.Combined test of the three indicators demonstrated that the sensitivity was 95.9%, specificity was 100% and accuracy was 96.9%,all of which were higher than other test combinations or singe test with statistical significance(P <0.05 ).Conclusion The combined test of C-reactive protein,amylase and lipase for acute pancreatitis patients doesn′t only improve early diagnostic efficiency,but also is helpful in disease severity judgment.