健康青年肠道病毒71型感染血清流行病学调查

摘要

Objective This study was conducted to investigate the distribution of enterovirus type71 (EV71) antibody IgG in healthy youth and to provide scientific evidence for further prevention.Methods A seroepidemiological study was conducted by using enzyme-linked immuno sorbent assay (ELISA).Serum samples of 364 recruits who came from 16 different provinces during the past eight years (from 2001 to 2008),were tested to detect EV71VP1 antibody IgG and the overall positive rate was analysed statistically.Results Serum EV71 antibody IgG ranged from 63.64％ to 100.00％ with an average rate of 87.64％ and regional differences.The higher levels were found in recruits from Shaanxi (100.00％),Hunan (100.00％),Fujian (95.46％) and Yunnan (95.46％) provinces,and lower level from other provinces.No significant correlation was found between the antibody IgG positive rate and education or occupation background of the recruits before their recruitment.Conclusion Currently,the healthy youth have already acquired firm immunity against EV71,and an epidemic outbreak of instestinal disease is impossoble.%目的 了解入伍新兵人群肠道病毒71型(EV71) IgG抗体的流行分布情况,为今后预防EV71感染提供科学依据.方法 采用血清流行病学调查方法,利用酶联免疫吸附试验(ELISA)技术,随机抽取北京军区空军2001至2008年8年期间入伍的来自16个省市的364名新兵血清进行了EV71VPI-IgG抗体检测并进行统计分析.结果364名新兵中,陕西省(100％)、湖南省(100％)、福建省(95.46％)和云南省(95.46％)阳性率较高,其余各省阳性检出率相对较低；阳性率63.64％～100.00％,平均阳性率为87.64％,各省间和沿海与内陆地区间阳性检出比较,显著性检验差异有统计学意义.入伍前工作与否,抗体阳性检出率无显著性差异.结论 目前,健康青年对EV71获得稳固免疫力,不易发生暴发流行.