西洋参茎叶皂苷对局灶性脑缺血大鼠血清中S-100β含量的影响

摘要

Objective: To observe panax quinquefolius saponin on cerebral ischemia in S - 100β protein in serum and to further explore its mechanism. Methods: The rats with incomplete cerebral ischemia were induced with fishing line in the middle cerebral artery occlusion (MCAO). PQS by ELISA on serum S - 100|3 protein content. Resu PQS could improve the symptoms of neurological impairment, lower blood S - 100p content. Conclusion: PQS has a protective effect on cerebral ischemia in rats. The mechanism may be related to endogenous astrocytes protective effects.%目的:观察西洋参茎叶皂苷(PS)对脑缺血大鼠血清中S-100β蛋白的影响,并进一步探讨其作用机制.方法:用线栓法制备大鼠局灶性脑缺血模型,采用酶联免疫法检测PQS对大鼠血清中S-100β蛋白含量的影响.结果:PQS能改善神经功能缺损的症状,降低血液中S一100β的含量.结论:PQS对大鼠脑缺血具有保护作用,其作用机制可能与星形胶质细胞的内源性保护作用有关.