拉曼光谱技术在药物晶型研究中应用进展

摘要

药物的不同晶型物质具有不同的分子排列或分子作用力,拉曼光谱可以反映分子极化率的变化,可用于药物多晶型的检测,该技术目前已被《欧洲药典》《英国药典》《中华人民共和国药典》 等收载为晶型检测方法.该文聚焦拉曼光谱技术在药物晶型研究中的应用,系统综述拉曼光谱在药物晶型定性、 定量、 动态过程等研究中的前沿进展,旨在为相关领域研究人员提供参考.%Different polymorphs of drugs have different molecular arrangements or molecular forces. Raman spectroscopy can reflect the change of molecular polarizability and can be used for the detection of drug polymorphs. The technology has been recorded for the analysis of polymorphism in European Pharmacacopoeia, British Pharamacopoeia and Chinese pharmacopoeia. This review focuses on the application of Raman spectroscopy in the study of pharmaceutical polymorphism. The advances in Raman spectroscopy in the qualitative, quantitative and dynamic processes of drug polymorphism are summarized and analyzed systematically, aiming to provide reference for researchers in related fields.