芳香族抗癫药物导致皮肤不良反应r与人类白细胞抗原基因多态性的相关性

摘要

以卡马西平为代表的芳香族抗癫药物作为治疗癫的一线药物,其导致的不良反应极大限制其临床应用,严重皮肤不良反应如史蒂文斯-约翰逊综合征及中毒性表皮坏死松解症等,尽管发生率低,但却往往致命.人类白细胞抗原(HLA)基因的多态性与芳香族抗癫药物导致的皮肤不良反应具有相关性,但其确切机制尚不清楚.该文通过对近年来芳香族抗癫药物导致的皮肤不良反应与HLA基因多态性之间的相关性研究进行综述,为进一步研究中国汉族人群的HLA易感基因提供理论基础,为实现抗癫药物使用的个体化治疗提供参考.%Aromatic antiepileptic drugs such as carbamazepine are the first-line treatment for epilepsy. The adverse reactions have greatly limited their clinical application. The occurrence rate of severe skin adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is low,but they are often fatal.Human leukocyte antigen (HLA) gene polymorphisms are reported to be related with skin adverse reactions caused by aromatic antiepileptic drugs,but the exact mechanism is unclear.This article will perform a review about the correlation between skin adverse reactions caused by aromatic antiepileptic drugs and HLA gene polymorphisms published in recent years,in order to provide theoretical basis for further study of HLA susceptibility genes in Chinese Han population,and provide a reference for achieving individualized treatment of epilepsy.