糖尿病合并肺结核患者诱导耐药性危险因素的回归分析

摘要

Objective:To analyze the risk factors associated with drug-resistant to patients with type 2 diabetes mellitus ( T2DM) and pulmonary tuberculosis by the regression analysis.Methods: The 248 pa-tients confirmed to pulmonary tuberculosis were chosen to retrospective analyze and divided into two groups , research group (98 cases, accomplished with T2DM) and control group (150 cases, non-accomplished with T2DM).The clinical data was collected to regression analysis, and the relative risk factors associated with drug-resistant were confirmed.Results: The factors of residence in rural areas, poor residence condition, treatment interruptions, long course of diseases, poor treatment compliance, smoking, HbA1c score, BMI score and hyperlipidemia were confirmed by the single factor chi-square test .Then the factors of treatment interruptions, long course of diseases, poor treatment compliance, smoking, HbA1c score were confirmed to risk factors associated with drug-resistant by multiple Logistic regression analysis .Conclusions: The pa-tients with the treatment interruptions, long course of diseases, poor treatment compliance, HbA1c score were been confirmed to produce drug resistance .%目的：分析2型糖尿病（T2DM）合并肺结核患者产生耐药性的相关危险因素。方法：选取248例我院治疗的结核病患者，依据是否合并T2DM分为：研究组，98例，合并T2DM；对照组，150例，未合并T2 DM。收集两组的临床资料，通过回归分析产生耐药性的相关危险因素。结果：经应用单因素卡方检验，农村居民、居住条件差、治疗不持续、病程时间较长、依从性差、吸烟、HbA1 c 值、BMI值、高脂血症等为相关危险因素，再经多因素非条件Logistic 回归分析显示，治疗不持续、病程超过1年、依从性差、吸烟、HbA1 c值为发生耐药的相关危险因素。结论：治疗过程有中断、病程长、依从性差以及血糖控制不佳的患者易出现耐药性。