老年慢性房颤患者血清热休克蛋白 70 和胱抑素 C 的表达及意义

摘要

Objective:To observe the expression of serum heat shock protein 70 ( HSP70) and Cystatin C ( CysC) in elderly patients with chronic atrial fibrillation ( CAF) , and investigate their significance in AF process.Method:100 patients with CAF, who were admitted to our hospital from January 2014 to January 2015, In AF group, 28 patients of paroxysmal AF, 31 patients of persistent AF and 41 patients of permanent AF.The control group was comprised of 55 age-and sex-matched subjects with no AF.The serum concen-trations of HSP70 and CysC were measured in two groups.Result:Compared with the control group, the lev-els of HSP70 and CysC were significantly improved in elderly patients with AF(P<0.05).And HSP70 and CysC concentration progressively increased in three subtypes, including paroxysmal, persistent and perma-nent AF.Logistic regression analysis revealed that HSP70 ( OR=0.629, P=0.023) and CysC ( OR=1.206, P=0.015) were independent predictors of the occurrence of AF, and there was a positive correlation between them C.onclusion:Elevated inflammatory cytokines HSP70 and CysC levels contribute closely to the occur-rence, development and persistence of AF.%目的:探讨老年慢性房颤患者血清热休克蛋白70(HSP70)及胱抑素C(CysC)表达水平及两者在房颤发生中的意义. 方法:选择2014年1月至2015年1月诊治的老年慢性房颤患者100例为房颤组,其中阵发性房颤28例,持续性房颤31例,永久性房颤41例. 另选取年龄、性别匹配的非房颤老年患者55例为对照组,检测两组血清HSP 70及CysC浓度. 结果:与对照组比较,房颤组患者血清HSP70及CysC水平明显升高(P<0.05),且在阵发性、持续性和永久性三种房颤亚型中,HSP70和Cysc浓度依次递增. Logistic回归分析显示HSP70(OR=0.629,P=0.023)和CysC(OR=1.206,P=0. 015)是房颤发生的独立预测因子,且两者呈正相关( r=-0.257,P<0.05). 结论:炎症因子HSP70 和CysC水平升高与房颤的发生发展密切相关.