妊娠期糖代谢异常的相关危险因素分析

摘要

Objective:To explore risk factors of abnormal glucose metabolism in gestation period, and provide the theory basis for the clinical prevention and treatment of gestational diabetes mellitus ( GDM ) . Method:A case-control study was conducted on 100 pregnant women with clinically confirmed gestational abnormal glucose metabolism as study group, and 100 pregnant women of same gestational weeks with normal glucose metabolism as control group from Jun.2011 to May 2014.The general information, gestational mate-rials and behaviors of the two groups were investigated and the risk factors of abnormal glucose metabolism in gestation period were analyzed.Result:Multi-factor logistic regression analysis showed that diabetes family history ( OR =2.398, 95%CI 1.042~5.012) , age was more than 28 years ( OR=1.413, 95%CI 1.322~4. 352) , BMI>24 ( OR=6.543, 95%CI 0.782~2.320) , abortion history ( OR=0.212, 95%CI 0.025~2. 256) , smoking history ( OR=0.246, 95%CI 0.045~3.452) were the risk factor of GDM morbidity.Con-clusion:Pregnant women with diabetes family history,>28 years, BMI>24,history of abortion and smoking should undergo gestational diabetes screening during early trimester of pregency.%目的：探讨妇女妊娠期糖代谢异常分布情况及发病的相关危险因素，为预防和控制妊娠期糖尿病提供理论依据。方法：以我院2011年6月至2014年5月保健门诊确诊的妊娠期糖代谢异常的孕产妇100例为病例组，以糖代谢正常及孕周相同的孕产妇100例为对照组。调查两组孕产妇一般情况，分析妊娠期糖代谢异常相关因素。结果：Logistic回归分析发现糖尿病遗传史（ OR＝2．398，95％， CI：1．042～5．012）、年龄＞28岁（ OR＝1．413，95％，CI：1．322～4．352）、体质指数＞24（ OR＝6．543，95％， CI：0．782～2．320）、流产史（ OR＝0．212，95％，CI：0．025～2．256）、吸烟史（ OR＝0．246，95％，CI：0．045～3．452）是妊娠期糖尿病发病的危险因素。结论：年龄＞28岁、体质指数＞24、糖尿病遗传史、流产史、吸烟史的孕妇应在妊娠早期进行妊娠期糖尿病筛查。