p53 p63及 p73在鼻咽癌患者组织中的表达及临床意义

摘要

Objective: To explore the expression and clinical significance of p 53, p63 and p73 in pa-tients with nasopharyngeal carcinoma .Methods: 89 cases of nasopharyngeal carcinoma patients diagnosed from August 2013 to August 2014 in our hospital were chosen as the observation group .The other 50 cases with chronic inflammatory disease were as the control group .The expression of p73, p63 and p53 in the two groups were compared, and the significance of its characteristics in different clinical cases were analyzed .Results:The positive rates of p73, p63 and p53 in the observation group were 67.42% (60 /89), 87.64% (78 /89) and 53.03% (48/89), which were significantly higher than those in the control group (28%), 36% (18 /50), 20% (10 /50).Positive rates of p73, p63 and p53 in different sex and age were not significantly differ -ent.In patients with nasopharyngeal carcinoma with lymphatic metastasis , the expression of p63, p53 was higher, and the positive rate of the expression of p 63 and p73 in TNM stage was higher and the pathological type was higher than that of the expression of p 63 in patients with nasopharyngeal carcinoma .The differences were statistically significant (P <0.05).Conclusion: The expression of p63, p73 and p53 gene in nasopha-ryngeal carcinoma patients is highly expressed , and it has significant correlation with clinical stage , lymph node metastasis and pathological typing .The monitoring of p53, p63 and p73 genes have good guidance for clinical treatment and prognosis of nasopharyngeal carcinoma .%目的：研究 P53、P63和 P73在鼻咽癌患者组织中的表达情况及临床意义。方法：选择2012年8月至2014年8月在我院确诊的鼻咽癌患者89例为观察组。并选择同期在我院接受治疗的鼻咽黏膜慢性炎症患者50例为对照组。对比两组组织中 P53、P63和 P73表达情况，并分析其不同临床病例特征的意义。结果：观察组 P53、P63和 P73阳性率为67．4％（60／89）、87．6％（78／89）以及53．0％（48／89），均高于对照组的28．0％（14／50）、36．0％（18／50）、20．0％（10／50），差异均具有统计学意义（P＜0．05）。不同性别、年龄中 p53、p63和 p73表达阳性率差异均无统计学意义。在具有颈淋巴转移的鼻咽癌患者中 p53、p63表达阳性率更高、在 TNM 分期为Ⅲ～Ⅳ期的鼻咽癌患者中 p63、p73表达阳性率更高以及病理类型为非角化癌鼻咽癌患者中 p63表达阳性率更高。差异均有统计学意义（P＜0．05）。结论：鼻咽癌患者组织中 P53、P63和 P73基因高表达，并且对临床分期、淋巴转移以及病理分型有显著的相关性。通过对 P53、P63和 P73在两种基因的监测，对鼻咽癌临床治疗和预后都有较好的指导作用。