目的:探讨叶酸联合维生素B12治疗老年冠心病慢性心力衰竭伴高同型半胱氨酸血症的疗效.方法:收集2015年6月至2017年6月入院的80例冠心病慢性心力衰竭伴高同型半胱氨酸血症老年患者随机分为两组,对照组患者给予对症治疗,实验组患者则加用叶酸与维生素B12,比较两组患者疾病相关参数、心衰分级与生活质量.结果:实验组患者治疗后HCY、NT-proBNP、TG、TC、LDL-C、MCP-1与IL-8水平组间比较均显著性低于对照组,E/A与HDL-C均显著性高于对照组;治疗后精力、生理职能、生理功能与总体健康评分组间比较均显著性高于对照组,存在显著性差异(P<0.01);治疗后 NY-HAⅠ~Ⅱ级率明显高于对照组,存在明显差异(P<0.05).结论:叶酸联合维生素B12治疗老年冠心病慢性心力衰竭伴高同型半胱氨酸血症的疗效显著,具有借鉴意义.%Objective:To investigate the efficacy of folic acid and vitamin B12in the treatment of elderly patients with chronic heart failure and hyperhomocysteinemia. Methods: A total of 80 elderly patients with CHD with hyperhomocysteinemia who were hospitalized from June 2015 to June 2017 were randomly divided into two groups. The patients in the control group were given symptomatic treatment while the patients in the experimental group Folic acid and vitamin B12were used to compare disease-related parameters,heart failure grade and quality of life in both groups. Results:The levels of HCY,NT-proBNP,TG,TC,LDL-C,MCP-1 and IL-8 in the experimental group were significantly lower than those in the control group (P <0.01). The NYHAⅠ ~ Ⅱlevel after treatment was significantly higher than that of the control group Group,there was a significant difference (P <0.05). Conclusion: The effect of folic acid combined with vitamin B12in the treatment of chronic heart failure and hyperhomocysteinemia in elderly patients with coronary heart disease is significant,and it is of reference significance.
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