Objective To investigate the association between the IFN-"y +874 site genetic polymorphisms and pathogenesis of pulmonary tuberculosis (TB) in Chinese Han population. Methods A case-control study was adopted, and the ARMS-PCR analysis was used to determine the genotype of IFN-γ + 874 site in case group ( n = 273) and control group (279). At the same time,the questionnaire investigation about TB-related environment risk factors was performed. Results There were no significant differences in different genotypes at IFN-γ + 874 site between the two groups ( P > 0. 05 ). After the exposure history and BCG vaccination history were adjusted the multifactor analysis showed the genotypes at IFN-γ + 874 site were still not correlated with the pathogenesis of pulmonary TB. Conclusion The IFN-γ + 874A/T genetic polymorphism may be not obviously related with the pathogenesis of pulmonary TB in Chinese Han population.%目的 探讨干扰素-γ(IFN-γ)基因多态性与中国汉族人群肺结核发病间的关系.方法 采用病例对照研究设计,应用扩增难控性突变系统PCR法检测(ARMS-PCR)病例组(n=273)及对照组(n=279)IFN-γ基因+874位点的基因型,同时开展对结核病相关环境危险因素进行问卷调查.结果 + 874位点各基因型在2组中的分布差异无统计学意义(P＞0.05).多因素分析中调整了接触史和卡介苗接种史后,+ 874基因型仍与肺结核发病无显著关联.结论 IFN-γ+874位点基因多态性可能与中国汉族人群肺结核发生的易感性无显著关联.
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