阿尔茨海默病与血管性痴呆血脂水平及血管性疾病危险因素的研究

摘要

目的 探讨阿尔茨海默病(AD)与血管性痴呆(VD)血脂水平及血管性疾病危险因素的差异.方法搜集25例AD患者(AD组),30例VD患者(VD组),另选取无痴呆患者30例作为对照组(CG组),比较3组血脂水平及血管性疾病危险因素的差异.结果 AD组和VD组血浆总胆固醇、三酰甘油、低密度脂蛋白均高于CG组(P<0.05或<0.01);AD组和VD 组载脂蛋白A1低于CG组(P<0.05或<0.01),VD 组α-脂蛋白高于AD 组和CG组(P<0.05或<0.01),VD组高血压、糖尿病及冠状动脉粥样硬化性心脏病危险因素高于CG组(P< 0.05或<0.01).结论 血浆总胆固醇、三酰甘油、低密度脂蛋白、α-脂蛋白增高,载脂蛋白A1降低可能与痴呆的发病有关,依据患者血管性疾病危险因素对临床医生更有效地诊断和鉴别诊断AD与VD有一定帮助.%Objective To investigate the change of blood fat levels and risk factors about vascular diseases in Alzheimer disease(AD) and vascular dementia(VD). Methods 25 AD patients and 30 VD patients were enrolled in the study,and the other 30 patients without dementia were served as controls. The blood fat levels and risk factors about blood vessel diseases were analyzed and compared among the three groups. Results The levels of total cholesterol,triglyceride and low density lipoprotein (LDL) in AD and VD group were significantly higher than those in control group ( P＜0.05 or P＜0.01 ). The levels of apoA in AD and VD group were significantly lower than those in control group ( P＜0.05 or P＜0.01 ). The levels of α-lipoprotein in VD group were obviously higher than those in AD group and control group ( P ＜ 0.01 ). The risk factors about vascular diseases including hypertension ,diabetes and the other risk factors of coronary heart disease in VD group were more than those of control group. ( P ＜ 0.05 or P ＜ 0.01 ). Conclusion The higher levels of patients'blood fat are related with the pathogenesis of AD and VD. The risk factors about vascular diseases can be helpful for the clinical diagnosis and differential diagnosis between AD and VD.