Objective To investigate the clinical efficacy of integrated traditional Chinese and western medicine in treatment of perimenopausal period cardiovascular disease. Methods One hundred patients with perimenopausal period cardiovascular diseases who were diagnosed and treated in our hospital were randomly divided into experimental group and control group,with 50 cases in each group. The patients in control group were treated by oral estradiol valerate,however,the patients in experimental group,on the basis of control group,were treated by Kuntai capsule and Kunbao pills. The Kupperman menopause indexes (KMI),glycosylated hemoglobin (HbA1c),high sensitive C reactive protein (hs-CRP),body mass index ( BMI),insulin resistance index (HOMA-IR),systolic blood pressure and serum low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C),apolipoprotein A1 (ApoA1),lipoprotein (a) Lp (a)]before and after treatment as well as the adverse reactions during treatment were observed and compared between the two groups. Results After treatment,KMI ,hot flashes sweating, anxiety, irritability, insomnia and amnesia scores were significantly decreased in both groups,as compared with those before treatment (P<0. 05),the decrease levels in experimental group were significantly lower than those in control group (P <0. 05). As compared with those before treatment,the hs-CRP levels were significantly decreased in experimental group after treatment (P<0. 05),moreover,which in experimental group were significantly lower than those in control group (P<0. 05). After treatment the BMI,systolic blood pressure levels , serum levels of TC,TG,LDL, HDL,APOA1 and Lp(a) were significantly decreased in both groups, as cdompared with those before treatment (P<0. 05), moreover the levels of these indexes in experimental group were significantly lower than those in control group (P<0. 05). However there were no significant differences in HbA1c and HOMA-IR levels before and after treatment between the two groups (P>0. 05). In addition the incidence rate of nausea and vomiting,vaginal bleeding,breast pain rate in experimental group was 6% ,which was significantly lower than that (18% ) in control group (P<0. 05). Conclusion The combination of traditional Chinese and western medicine in treatment of perimenopausal period cardiovascular disease can effectively relieve the clinical symptoms of patients,improve patient's indexes,decrease incidence of adverse reactions,with higher safety, therefor,which is worth using widely in clinical practice.%目的 探讨中西医结合治疗围绝经期心血管病的临床疗效.方法 选择100例诊断明确的围绝经期患者,随机分为试验组和对照组,每组50例:对照组给予戊酸雌二醇服用,试验组在对照组基础上联合应用坤泰胶囊和坤宝丸.于治疗前及治疗后进行测量 Kupperman 绝经指数(KMI)、糖化血红蛋白(HbA1c)、超敏C-反应蛋白(hs-CRP)、体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)、收缩压及血脂[三酰甘油( TG)、总胆固醇( TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(APOA1)及脂蛋白(a) Lp(a)],并记录2组患者治疗期间出现的不良反应情况.结果 治疗后2 组患者KMI、潮热汗出、焦虑、易怒、失眠健忘评分较治疗前明显降低(P<0. 05),且试验组显著低于对照组,差异有统计学意义(P<0. 05);与治疗前比较,治疗后试验组hs-CRP水平显著降低,差异有统计学意义(P<0. 05),且试验组hs-CRP水平显著低于对照组,差异有统计学意义(P<0. 05);治疗后2组患者BMI、收缩压,血清TC、TG、LDL、HDL、APOA1及Lp(a)水平较治疗前显著降低,差异有统计学意义(P<0. 05);且试验组显著低于对照组,差异有统计学意义(P<0. 05);但治疗前后2组患者HbA1c及HOMA-IR水平差异无统计学意义(P>0. 05);试验组出现恶心呕吐、阴道出血、乳房胀痛等不良反应率显著低于对照组,差异有统计学意义(P<0. 05).结论 中西医结合治疗围绝经期心血管病效果显著,能有效缓解患者主要的临床症状,改善患者各项检测指标,且不良反应发生率低,安全性高,值得临床广泛应用.
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