呼出气一氧化氮水平在支气管哮喘患者诊疗中的应用价值分析

摘要

Objective To investigate the value of exhaled nitric oxide (FeNO) levels in diagnosis and treatment of bronchial asthma.Methods A total of 120 patients with bronchial asthma who were treated in our hospital from December 2015 to April 2017 were enrolled in the study. According to patient's condition,these patients were divided into mild group (n=60) and moderate group ( n =60),at the same time,60 healthy subjects were served as control group.The patients in both groups were treated by intravenous drip with doxofylline 0.3g,once a day+oral montelukast 10mg,once a day(at night)+ aerosol inhalation of salbutamol sulfate 5mg and budesonide 2mg,three times a day. The FeNO levels and pulmonary function indexes including FEV1 and PEF before and after treatment were detected and compared among the three groups. Results The FeNO levels before and after treatment in mild group and moderate group were significantly higher than those in control group,moreover,which in moderate group were significantly higher than those in mild group ( P <0.05). Moreover the levels of FEV1 and PEF in mild group and moderate group were significantly lower than those in control group,which in moderate group were significantly lower than those in mild group ( P <0.05). Before treatment,the levels of FeNO were negatively correlated with those of FEV1 and PEF ( r = -0.168,0.154,P <0.05),however, after treatment the levels of FeNO were not correlated with those of FEV1 and PEF ( P >0.05).Conclusion The FeNO levels have good application value in diagnosis and treatment of bronchial asthma,which can direct the treatment of patients with bronchial asthma,thus, which is worth using widely in clinical practice.%目的 研究呼出气一氧化氮(FeNO)水平在支气管哮喘患者诊疗中的应用价值.方法 选取120例支气管哮喘患者进行研究.根据患者病情状况分为轻度组(n=60)和中度组(n=60),并选择60例健康体检人员作为对照组进行分析.轻度组和中度组患者均给予0.3 g多索茶碱静脉点滴(1次/d) +10 mg孟鲁斯特了口服(1次/晚)+5 mg硫酸沙丁胺醇和2 mg布地奈德雾化剂雾化吸入(3次/d).治疗前后,分别对轻中度患者及健康对照组的FeNO及肺功能状况[第1秒用力呼气容积(FEV1)、最大呼气峰流速(PEF)]进行检测分析.结果 治疗前和治疗后,轻度组和中度组的FeNO水平明显高于对照组,中度组FeNO水平明显高于轻度组,差异均有统计学意义(P<0.05);轻度组和中度组的FEV1及PEF水平明显低于对照组,中度组FEV1及PEF水平明显低于轻度组,差异均有统计学意义(P<0.05).治疗前,FeNO水平与FEV1及PEF呈负相关关系(r值分别为-0.168、-0.154,P<0.05);治疗后,FeNO水平与FEV1及PEF无相关性(r值分别为0.738、0.072,P>0.05).结论 FeNO水平在支气管哮喘患者诊疗中的应用价值良好,可指导支气管哮喘患者的治疗,值得广泛推广应用.