乳腺癌紫杉醇耐药患者应用卡培他滨与多西他赛联合中医治疗的疗效及安全性

摘要

Objective To observe the efficacy and safety of combination of Capecitabine, Docetaxel and Chinese medicine treatment on patients with breast cancer Paclitaxel resistance.Methods 78 patients with breast cancer Paclitaxel resistance were randomly divided into two groups.33 cases in control group mainly adopt capecit-abine and Docetaxel for the conventional western medicine treatment,45 cases in the treatment group received the combined application of Chinese medicine treatment on the basis of the control group treatment.The near future cura-tive effect,the median survival time ( MST) ,2 years of survival rate and all kinds of the occurrence of adverse reac-tions were compared in the two groups after 4 times chemotherapy.Results There was no significant difference be-tween two groups on the near future curative effect (P>0.05).The incidence of adverse reactions such as diarrhea, fatigue,hair loss,paralysis,mucositis,nausea,vomiting,thrombocytopenia,liver function damage,muscle joint pain in control group was higher than that in treatment group (P<0.05).24 months follow-up was finished in the 2 groups. A patient was lost to follow-up in two groups,the MST of the control was 12 months,the MST of treatment group was 14 months,and there was no statistical significance between two groups on the MST (P>0.05).Conclusion Com-bination of Capecitabine,Docetaxel and Chinese medicine treatment on patients with breast cancer Paclitaxel resist-ance although not able to significantly improve the patient's recent curative effect and survival,but can significantly re-duce some of the adverse reactions during chemotherapy.%目的：观察乳腺癌紫杉醇耐药患者在使用卡培他滨与多西他赛治疗的基础上联合中医治疗的临床疗效及安全性。方法将78例乳腺癌紫杉醇耐药患者随机分为2组。对照组33例主要采用卡培他滨与多西他赛为主的西医常规方案进行治疗，治疗组45例在对照组治疗基础上联合中医疗法进行治疗。比较2组进行4次化疗后的近期疗效、中位生存期（ MST）及2组各种不良反应的发生情况。结果2组近期疗效比较差异无统计学意义（ P＞0．05）；对2组的不良反应腹泻、乏力、脱发、麻痹感、黏膜炎、恶心呕吐、血小板减少、肝功能损害、肌肉关节疼痛及其他症状进行统计分析发现：对照组在以上不良反应的发生率上均高于对照组（P＜0．05）；对2组进行为期24个月的随访观察，结果2组均有1例患者失访，对照组的MST为12个月，治疗组的MST为14个月，2组MST比较差异无统计学意义（P＞0．05）。结论对乳腺癌紫杉醇耐药患者在使用卡培他滨与多西他赛治疗的基础上联合中医治疗虽然不能够显著的改善患者的近期疗效和生存期，但是可以显著的减轻患者化疗期间的一些不良反应。