抑郁情绪对脑梗死患者血清高敏C反应蛋白和肿瘤坏死因子-α的影响

摘要

Objective To discuss the clinical influence of depression on serum high sensitivity C-reactive pro-tein (hs-CRP) and tumor necrosis factor-α(TNF-α) in patients with cerebral infarction. Methods Forty-five patients diagnosed as cerebral infarction with depressed mood according to Self-Rating Depression Scale (SDS) and Hamilton Depression Rating Scale (HAMD) were selected as the depression group, and 45 patients without depressed mood were divided into the non-depression group. The serum hs-CRP and TNF-αwere compared between the two groups. The 90 patients were enrolled as the mild (n=52), moderate (n=22), and severe (n=16) infarction group according to the brain CT, and then the serum hs-CRP and TNF-αwere compared between the three groups. Results The serum hs-CRP and TNF-αlevels in the depression group were significantly higher than those in the non-depression group (P<0.01). Theserum hs-CRP and TNF-αlevels in the mild infarction group were significantly lower than those in the moderate in-farction group (P<0.01), and the levels in the moderate infarction group were significantly lower than those in the se-vere infarction group (P<0.01). Conclusion Depression can aggravate the inflammatory reaction in patients with ce-rebral infarction, and promote the increase of serum hs-CRP, TNF-α, thereby aggravate illness. Patients with cerebral infarction should be given active intervention to reduce the negative emotions, improve the therapeutic effects and prognosis.%目的 探讨抑郁情绪对脑梗死患者血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)的影响.方法 选取根据抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)评分判断为抑郁情绪的脑梗死患者45例作为抑郁组,选取无抑郁情绪的脑梗死患者45例作为非抑郁组,比较两组患者的血清hs-CRP及TNF-α水平.另外将上述90例脑梗死患者根据颅脑CT检查结果分为轻度(n=52)、中度(n=22)和重度(n=16)梗死组,比较三组患者的血清hs-CRP及TNF-α水平.结果 抑郁组患者的血清hs-CRP、TNF-α均显著高于非抑郁组,差异均具有显著统计学意义(P<0.01);轻度梗死组患者hs-CRP及TNF-α均显著低于中度梗死组,中度梗死组均显著低于重度梗死组,差异均具有显著统计学意义(P<0.01).结论 抑郁情绪将加重脑梗死患者的炎症反应,促使血清hs-CRP、TNF-α的增高,进而加重病情,因此脑梗死患者应给予积极心理干预,减轻其不良情绪,提高治疗效果,改善预后.