阿立哌唑联合氟西汀与奥氮平联合氟西汀治疗女性难治性抑郁的开放式对照研究

摘要

目的 探讨氟西汀联合阿立哌唑与氟西汀联合奥氮平治疗难治性抑郁的疗效与安全性.方法 将48例难治性抑郁患者随机分为1组(氟西汀+阿立哌唑)24例和2组(氟西汀+奥氮平)24例,观察8周.于治疗前和治疗1周、2周、4周及6周末采用汉密尔顿抑郁量表(Hamilton depressive,HAMD-17)评定疗效,用不良反应量表(TESS)评定不良反应.结果 阿立哌唑组显效率为55.0%,奥氮平组为52.3%.奥氮平组第4周HAMD评分低于阿立哌唑组,差异无显著性.阿立哌唑组不良反应较少.结论 阿立哌唑联合氟西汀治疗难治性抑郁的疗效好,起效快,且不良反应少.%　　Objective To investigate the efficacy of fluoxetine combined with aripiprazole and combination of fluoxetine and olanzapine in the treatment of refractory depression curative effect and safety. Methods 48 patients with refractory depression patients were randomly divided into 1 groups (fluoxetine plus aripiprazole) in 24 patients and 2 groups (fluoxetine and olanzapine) in 24 cases, observation of 8 weeks.Before treatment and 1 weeks of treatment, 2 weeks, 4 weeks and 6 weeks with the Hamilton Depression Rating Scale (Hamilton depressive, HAMD-17) assessment of efficacy, with adverse effect scale (TESS) assessment of adverse reactions. Results The effective rate was 55.0% in aripiprazole group, the olanzapine group 52.3%.Olanzapine group fourth weeks HAMD score lower than in aripiprazole group, no significant difference.Aripiprazole group and less adverse reaction. Conclusion Aripiprazole combined with fluoxetine in the treatment of refractory depression has good curative effect, quick effect, and less adverse reaction.