血管内皮生长因子表达及微血管密度与头颈肿瘤发展和转移的关系

摘要

研究血管内皮细胞生因子(VBGV)的表达及微血管密度(MVD)与头颈肿瘤发展及转移的关系.应用免疫组织化学S-P法,检测32例头颈恶性肿瘤、20例头颈良性肿瘤、16例头颈部无瘤组织石蜡标本组织中的血管内皮细胞生长因子(VEGF)的表达、微血管密度(MVD).头颈恶性肿瘤组织VEGF的表达及MVD明显高于头颈良性肿瘤及头颈无瘤组织(P<0.05),转移组比较非转移组高(P<0.05).此外,在头颈肿瘤的发展及转移中VEGF的表达及MVD具有显著的正相关关系(r=0.398,<0.05).VEGF与头颈肿瘤血管生成有密切关系;VEGF的表达和MVD的增高对头颈肿瘤发展及转移有促进作用,其检测有可能作为头颈肿瘤预后的指标.%To investigate whether the expression of vascular endothelial growth factor(VEGF) and microvessel density (MVD) is related to the progression and metastasis of head and neck tumor,he VEGF expression and MVD were assessed by immunohistochemistry using rabbit anti-human VEGF antibody and rabbit anti-human factor Ⅷ-related antigen antibody. The VEGF expression and MVD in malignant tumors of head and neck were higher than those in benign tumors and non-tumor tissues in head and neck tissue (P<0.05).The VEGF expression and MVD in malignant tumor with metastasis was significantly increased as compared with those without metastasis (P<0.05).There was a close positive correlation between VEGF expression and MVD(r=0.398,<0.05).Thus,he VEGF expression is closely correlated with angiogenesis.It is revealed that the increases in VEGF expression and MVD may promote the progression and metastasis of head and neck tumor.Thus,EGF and MVD may have prognostic value in head and neck tumor.