毛郁金乙醇提取物降血脂作用研究

摘要

Objective]The antihyperliposis function of the ethanol extract from Curcuma aromatica was studied on rats in order to provide the basis for its comprehensive development and utilization.[Methods]High lip-id rat model was prepared by feeding a high-fat diet and gastric perfusion of intralipid,then de-livered with different doses of the ethanol ex-tract from Curcuma aromatica .All experimen-tal rats were divided into 6 groups:A normal control group,a high lipid model group,a posi-tive group(Simvastatin)and three groups of eth-anol extract from Curcuma aromatica with the equivalent weight of 1 8 g crude drug · kg-1 · d-1 ,1 2 g crude drug · kg-1 · d-1 and 6 g crude drug·kg-1 · d-1 ,respectively.[Results]The ethanol extract from Curcuma aromatica could decrease the value of total cholesterol(CHOL),triglyceride (TG)and the low density lipopro-tein-cholesterol (LDL-C)in the blood of rats,and also increase the value of high density lipo-protein-cholesterol (HDL-C).The CHOL and LDL-C decreasing effects ranked as:high>mid-dle>low dose group.The middle dose group has a better effect on TG decreasing and HDL-C increasing.All the dose groups of Curcuma aromatica have significantly lower levels of LDL-C (P<0.01).[Conclusion]The ethanol extract from Curcuma aromatica shows clear effects on antihyperliposis.%【目的】研究毛郁金(Curcumaaromatica )乙醇提取物降血脂作用,为其综合开发利用提供依据。【方法】通过高脂饲料喂养及脂肪乳剂灌胃,建立高脂血症大鼠模型,连续3周给予毛郁金乙醇提取物进行治疗,设正常组、高脂模型组、辛伐他汀组和毛郁金乙醇提取物高、中、低剂量(生药18 g·kg-1·d-1,12 g·kg-1·d-1,6 g·kg-1·d-1)组,以动物实验研究毛郁金乙醇提取物降血脂的作用。【结果】毛郁金乙醇提取物可降低大鼠血清总胆固醇(CHOL)、三酰甘油(TG)和低密度脂蛋白(LDL-C)的含量,并提高血清高密度脂蛋白(HDL-C)含量,对血清CHOL、LDL-C的降低作用：高>中>低剂量组,中剂量组对降低 TG、升高 HDL-C 含量具有较好作用,毛郁金各给药组均对大鼠血清 LDL-C含量有极显著降低作用。【结论】毛郁金乙醇提取物具有明显的降血脂作用。