南宁地区221株淋球菌对青霉素、壮观霉素的敏感性测定

摘要

目的：了解南宁地区淋球菌对青霉素、壮观霉素的敏感性。方法：我们于1996年至1999年对221株淋球菌临床分离株以琼脂稀释法测定青霉素、壮观霉素的最小抑菌浓度(MIC)。结果：7株(3.17％)为产青霉素酶淋球菌(PPNG)。青霉素MIC范围为0.008～16mg/L；2.71％菌株对青霉素敏感，36.20％为低敏，61.09％为耐药。其中1996至1999年各年耐药率分别为23.92％、37.10％、89.16％、90.00％。壮观霉素MIC范围2～＞128mg/L；92.76％菌株对壮观霉素敏感，7.24％菌株为耐药；1999年未发现耐壮观霉素菌株。结论：南宁地区淋球菌对青霉素耐药比率较高，且呈逐年上升趋势。出现了耐壮观霉素的菌株。持续性监测青霉素、壮观霉素对临床合理用药十分重要。%Objective: To measure the susceptibility of Neisseria gonorrhoeae to penicillin and spetinomycin in Nan ning. Methods:221 clinical isolates of Neisseria gonokrrhoeae abtained from patients with gonorrhea in Nanning were tesed for their susceptiblities to penicillin and spectinomycin in vitro. The mininum inhibitory concentrations (MIC) of penicillin and spectinomycin were determined by agar dilution method. Rusults: 7 strains (3.17%) were penicilinase producers (PPNG).rn The MIC ranges were from 0.008mg/L to 16mg/L for Penicillin. 2.71% of the isolates were susceptible to penicillin,36.20% were less sensitive; 61.09% exhibited resistance to penicillin. The prevalence of resistant gonococci every year was 23.92%, 37.1%, 89.16%, 90% respectively in 1996～1999. The MIC ranges were from 2mg/L to＞128mg/L for spectinomycin.92.76% of the isolates were susceptible to spectinomycin, 7.24% exhibited resistance to spectinomycin. None of the isolates were detected to be resistant of spectinomycin in 1999. Conclusion: A high proportion of goncoccal isolates remain resistant to penicillin, with the emergence of spectinomycin resistance strains in Nanning. For the treatment of gonorrhea, continued surveillance of sensitivity of contemporary gonococci to penicillin and spectinomycin is very important.