醋酸去氨加压素治疗儿童单症状性夜间遗尿症的临床疗效

摘要

Objective To explore the clinical efficacy of desmopressin acetate(DDAVP) on children with monosymptomatic nocturnal enuresis(MNE).Methods A total of 158 children with MNE were divided into experimental group and control group using random number table,with 79 cases in each group.Behavioral psychotherapy was conducted in both groups,and the experimental group was also administered DDAVP.The clinical efficacy,recurrence rates at one and three months after therapy discontinuation,maximum flow rates before and after treatment were compared between the two groups.Results The total clinically effective rate of the experimental group was higher than that of the control group(P<0.05).The recurrence rates at one and three months after therapy discontinuation were lower in the experimental group compared to the control group(P<0.05).The maximum flow rate and urine volume reduced in both groups with the increase of the observation time(P<0.05),and the levels of the indices above in the experimental group were lower than those in the control group after treatment(P<0.05).Conclusion DDAVP obtains a significant efficacy on children with MNE.%目的 探讨醋酸去氨加压素(DDAVP)治疗儿童单症状性夜间遗尿症(MNE)的临床疗效.方法 将158例MNE患儿按随机数字表法分为试验组及对照组,每组79例.两组均进行行为心理治疗,试验组加用DDAVP.比较两组患者临床疗效、停止治疗后1个月及3个月复发率、治疗前后最大尿流率等指标.结果 试验组患儿临床治疗总有效率高于对照组(P<0.05);停止治疗后1个月及3个月试验组的复发率均低于对照组(均P<0.05).两组最大尿流率及尿量均随观察时间延长而减少(P<0.05),且治疗后试验组以上指标均低于对照组(P<0.05).结论 DDAVP治疗儿童MNE疗效显著.