原发于直肠、肺的神经内分泌肿瘤的临床病理特征对患者生存率的影响

摘要

目的 探讨原发于直肠、肺的神经内分泌肿瘤的临床病理特征对患者生存率的影响.方法 回顾性分析经病理确诊为原发于直肠的神经内分泌肿瘤107例患者和原发于肺的神经内分泌肿瘤109例患者的临床资料,计算不同临床病理特征的患者5年生存率,并分析临床病理特征对生存率的影响.结果 原发于直肠的神经内分泌肿瘤患者中,<55岁、淋巴结无转移、无远处转移、TNM分期Ⅰ~Ⅱ期、类癌的患者5年生存率分别高于≥55岁、淋巴结转移、远处转移、TNM分期Ⅲ~Ⅳ期、不典型类癌及神经内分泌癌/小细胞癌的患者(P<0.05);不同肿瘤直径、T分期患者的5年生存率比较,差异也有统计学意义(P<0.05).在原发于肺的神经内分泌肿瘤患者中,<55岁、典型类癌、远处无转移、TNM分期Ⅰ~Ⅱ期和周围型肿瘤者的5年生存率分别高于≥55岁、不典型类癌、远处有转移、TNM分期Ⅲ~Ⅳ期和中央型的患者(P<0.05).结论 年龄、TNM分期、病理类型、远处转移可能同时影响原发于肺和直肠神经内分泌肿瘤患者的生存率.%Objective To explore the effect of clinicopathological features on the survival rate in patients with primary rectal/pulmonary neuroendocrine tumors.Methods Clinical data of 107 patients pathologically diagnosed as primary rectal neuroendocrine tumors and 109 patients as primary pulmonary neuroendocrine tumors were retrospectively analyzed.The 5-year survival rates of patients with different clinicopathological features were calculated,and the effect of clinicopathological features on the survival rate was analyzed.Results Among the patients with primary rectal neuroendocrine tumors,the 5-year survival rates of the patients with age<55 years,without lymph node metastasis,without distant metastasis,with TNM stageⅠ-Ⅱ,and with carcinoid were higher than those of the patients with age ≥55 years,with lymph node metastasis,with distant metastasis,with TNM stage Ⅲ-Ⅳ,and with untypical carcinoid and pulmonary neuroendocrine cancer/small cell cancer respectively(P<0.05).And there was significant difference in the 5-year survival rate between the patients with different tumor sizes or different T stages(P<0.05).Among the patients with primary pulmonary neuroendocrine tumors,the 5-year survival rates of the patients with age<55 years,typical carcinoid,without distant metastasis,with TNM stageⅠ-Ⅱ and with peripheral type carcinoma were higher than those of the patients with age ≥55 years,untypical carcinoid,with distant metastasis,with TNM stage Ⅲ-Ⅳ and with central type carcinoma respectively(P<0.05).Conclusion Age,TNM stage,pathological type and distant metastasis are probably the common factors influencing the prognosis of the patients with primary rectal and pulmonary neuroendocrine tumors.