急性冠脉综合征患者中性粒细胞-淋巴细胞比值、纤维蛋白原及血清脂蛋白(a)水平及其与病变严重程度的相关性

摘要

目的 探讨急性冠脉综合征(ACS)患者中性粒细胞-淋巴细胞比值(NLR)、纤维蛋白原及血清脂蛋白(a)水平及其与ACS病变严重程度的相关性.方法 选取ACS患者150例,其中轻度病变组(Gensini评分≤45分)70例,重度病变组(Gensini评分>45分)80例,另选取冠状动脉造影正常者60例作为对照组.比较3组的NLR、纤维蛋白原及血清脂蛋白(a)水平,并分析ACS患者以上3个指标与Gensini评分的相关性.结果 对照组、轻度病变组及重度病变组的Gensini评分、NLR、纤维蛋白原及血清脂蛋白(a)均依次升高(均P<0.05).轻度病变组Gensini评分与NLR、血清脂蛋白(a)水平均呈正相关(均P<0.05),而与纤维蛋白原水平无相关性(P>0.05);重度病变组Gensini评分与NLR、纤维蛋白原和血清脂蛋白(a)水平均呈正相关(均P<0.05).结论 ACS患者的NLR、纤维蛋白原及血清脂蛋白(a)水平升高,三者对于预测ACS 的发生及病情严重程度评估具有一定的意义.%Objective To investigate the levels of neutrophils to lymphocyte ratio(NLR),fibrinogen and serum lipoprotein(a) in patients with acute coronary syndrome(ACS) and their correlation with disease severity.Methods A total of 150 patients with ACS were enrolled and were divided into mild lesion group(Gensini score≤45 points,n=70) and severe lesion group(Gensini score>45 points,n=80). Sixty subjects with normal coronary arteriography were enrolled as control group.The levels of NLR,fibrinogen and serum lipoprotein(a) were compared among the three groups,and the correlation of the three indices above with Gensini score was analyzed.Results The Gensini score,as well as the levels of NLR,fibrinogen and serum lipoprotein(a),increased in the order of the control group,the mild lesion group and the severe lesion group(P<0.05).In the mild lesion group,the Gensini score positively correlated with the levels of NLR and serum lipoprotein(a)(all P<0.05),and did not correlate with fibrinogen(P>0.05).In the severe lesion group,the Gensini score positively correlated with the levels of NLR,fibrinogen and serum lipoprotein(a)(all P<0.05).Conclusion The levels of NLR,fibrinogen and serum lipoprotein(a) increase in the patients with ACS,and the three indicators obtain great significance in predicting the occurrence of ACS and evaluating its severity degree.