Wistar rats were injected intraperitoneally with lead acetate in dosage of 659 mg/kg body every day.At the 4th week,the dosage of lead acetate was reduced to 329.5 mg/kg body.After the 8th week poisoning was stopped.The results show that the rats appear higher urinary Pb,Zn,Ca along with lead poisoning.Calcium,zinc and iron concentrations in brain,liver and kidney all rise to a certain extent.Liver calcium,zinc and iron,kidney calcium and zinc increase obviously(P＜0.01).After the 8th week,brain lead decrease obviously(P＜0.01).liver lead does not change obviously.Kidney lead raises extremely and rises about 13 times from 47.93 μmol/L to 633.85 μmol/L(P＜0.01).%Wistar大鼠每天腹腔注射醋酸铅659 mg/kg，在第4周醋酸铅剂量降至329.5 mg/kg，8周停止染毒。结果表明，随着铅染毒，大鼠出现高尿铅、高尿锌、高尿钙；脑、肝、肾中铁、锌、钙却都有不同程度提高，肝脏中锌、钙、铁，肾脏中锌、钙增加极明显；在8周停止染毒后，脑铅含量大幅度降低(P＜0.01)，肝脏铅却梢有上升(P＞0.05)，肾铅急剧增加，从47.9320 μmol/L升至633.85 μmol/L，大约上升13倍(P＜0.01)。
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